Risk Factors and Prediction Score of ARDS After Cardiac Surgery
2021年1月28日 更新者:Guangfa Zhu、Beijing Anzhen Hospital
Acute respiratory distress syndrome following cardiac surgery severely affects the prognosis of patients; the mortality is up to 40%.
Although experience many years of research and exploration, the effective methods for the treatment of acute respiratory distress syndrome is still relatively limited at present, including lung protective mechanical ventilation respiratory support, fluid management, glucocorticoid and other integrated organ function maintenance measures.
It is currently the research of acute respiratory distress syndrome aims at the early discovery and takes effective measures to prevent its occurrence, hoping to improve the prognosis of patients.
According to risk factors is established through the analysis of lung injury score early warning system, the early identification of acute respiratory distress syndrome patients at high risk, before the occurrence of acute respiratory distress syndrome take corresponding preventive measures can effectively reduce the incidence rate and mortality.
So far, domestic and foreign research on the establishment of acute respiratory distress syndrome scoring early warning system is less.
Cardiac surgery has significant characteristics, type of operation, location, operation, intraoperative blood transfusion and oxygenation, postoperative factors, are likely to be the factors of acute respiratory distress syndrome.
As far as investigators know, so far there are few specialized for acute respiratory distress syndrome predicting lung injury after cardiac surgery.
This study will be completed after the implementation of individualized dynamic lung injury score evaluation of cardiac surgery patients, identification of high-risk acute respiratory distress syndrome patients, to assist clinicians in early decision, take preventive measures.
This study will improve the prognosis of acute respiratory distress syndrome patients after cardiac surgery; it is of great significance to improve the level of intensive care after cardiac surgery.
調査の概要
研究の種類
観察的
入学 (実際)
1333
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Beijing
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Beijing、Beijing、中国、100029
- Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 子
- 大人
- 高齢者
健康ボランティアの受け入れ
いいえ
受講資格のある性別
全て
サンプリング方法
非確率サンプル
調査対象母集団
Patients of cardiac surgery in Beijing Anzhen hospital
説明
Inclusion Criteria:
- Retrospective group: cardiac surgery patients accepted from Jan 2013 to Dec 2015
- Prospective group: cardiac surgery patients accepted from 2017 January to December
Exclusion Criteria:
- refused to participate in the study
- age less than 18 years old
- before operation performed mechanical ventilation
- before operation underwent IABP treatment
- before operation continuous renal replacement therapy
- before operation undergoing in vitro membrane oxygenator treatment
- before operation has the pulmonary imaging showed bilateral pulmonary diffuse exudation of interstitial pneumonia, pulmonary infection or respiratory failure
- the major trauma, sepsis, aspiration, shock, acute heart failure
- before operation diagnosed as malignant tumor
- Incomplete data.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
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ARDS
ARDS patients after cardiac surgery
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This is a clinical observational study, no intervention was included.
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non-ARDS
non-ARDS patients after cardiac surgery
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This is a clinical observational study, no intervention was included.
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propective group
patients of cardiac surgery including ARDS and non-ARDS patients
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This is a clinical observational study, no intervention was included.
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
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The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
時間枠:up to 12months
|
up to 12months
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The number of patients of cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
時間枠:up to 12months
|
up to 12months
|
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The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
時間枠:up to 12months
|
up to 12months
|
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The number of patients of cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
時間枠:up to 12months
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up to 12months
|
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The number of diabetic patients in ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The number of diabetic patients in non-ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The number of chronic obstructive pulmonary disease patients in ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The number of chronic obstructive pulmonary disease patients in non-ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The type of operation in ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The type of operation in non-ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The body mass index in ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The body mass index in non-ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The heart function in ARDS group before operation.
時間枠:up to 1 month
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up to 1 month
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The heart function in non-ARDS group before operation.
時間枠:up to 1 month
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up to 1 month
|
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The oxygenation in ARDS group before operation.
時間枠:up to 1 month
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up to 1 month
|
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The oxygenation in non-ARDS group before operation.
時間枠:up to 1 month
|
up to 1 month
|
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The drug taken by patients in ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The drug taken by patients in non-ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
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The nutrition situation of patients in ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The nutrition situation of patients in non-ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The process of operation in ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The process of operation in non-ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The blood transfusion of patients during operation in ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
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The blood transfusion of patients during operation in non-ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
|
The oxygenation of patients during operation in ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
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The oxygenation of patients during operation in non-ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
|
The drug taken by patients after operation in ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
|
The drug taken by patients after operation in non-ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
|
The oxygenation of patients after operation in ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
|
The oxygenation of patients after operation in non-ARDS group.
時間枠:up to 1 month
|
up to 1 month
|
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The situation of mechanical ventilation of patients after operation in ARDS group.
時間枠:up to 1 month
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up to 1 month
|
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The situation of mechanical ventilation of patients after operation in non-ARDS group.
時間枠:up to 1 month
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up to 1 month
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二次結果の測定
結果測定 |
時間枠 |
|---|---|
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The mortality of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
時間枠:up to 1months
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up to 1months
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The morbidity of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
時間枠:up to 1months
|
up to 1months
|
協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
スポンサー
捜査官
- スタディチェア:Guangfa Zhu、Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
一般刊行物
- ARDS Definition Task Force; Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012 Jun 20;307(23):2526-33. doi: 10.1001/jama.2012.5669.
- Kogan A, Preisman S, Levin S, Raanani E, Sternik L. Adult respiratory distress syndrome following cardiac surgery. J Card Surg. 2014 Jan;29(1):41-6. doi: 10.1111/jocs.12264. Epub 2013 Dec 3.
- Berg KS, Stenseth R, Pleym H, Wahba A, Videm V. Mortality risk prediction in cardiac surgery: comparing a novel model with the EuroSCORE. Acta Anaesthesiol Scand. 2011 Mar;55(3):313-21. doi: 10.1111/j.1399-6576.2010.02393.x.
- Forel JM, Voillet F, Pulina D, Gacouin A, Perrin G, Barrau K, Jaber S, Arnal JM, Fathallah M, Auquier P, Roch A, Azoulay E, Papazian L. Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy. Crit Care. 2012 Dec 12;16(2):R65. doi: 10.1186/cc11312.
- Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR 3rd, Morris AH; National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med. 2015 Feb;43(2):288-95. doi: 10.1097/CCM.0000000000000715.
- Festic E, Kor DJ, Gajic O. Prevention of acute respiratory distress syndrome. Curr Opin Crit Care. 2015 Feb;21(1):82-90. doi: 10.1097/MCC.0000000000000174.
- Rubenfeld GD. Who cares about preventing acute respiratory distress syndrome? Am J Respir Crit Care Med. 2015 Feb 1;191(3):255-60. doi: 10.1164/rccm.201408-1574CP.
- Beitler JR, Schoenfeld DA, Thompson BT. Preventing ARDS: progress, promise, and pitfalls. Chest. 2014 Oct;146(4):1102-1113. doi: 10.1378/chest.14-0555.
- Milot J, Perron J, Lacasse Y, Letourneau L, Cartier PC, Maltais F. Incidence and predictors of ARDS after cardiac surgery. Chest. 2001 Mar;119(3):884-8. doi: 10.1378/chest.119.3.884.
- Michalopoulos A, Prapas S, Falagas ME. The incidence of adult respiratory distress syndrome in patients undergoing off-pump coronary artery bypass grafting surgery. Eur J Anaesthesiol. 2006 Jan;23(1):80. doi: 10.1017/S0265021505211821. No abstract available.
- Vakili M, Shirani S, Paknejad O, Yousefshahi F. Acute Respiratory Distress Syndrome diagnosis after coronary artery bypass: comparison between diagnostic criteria and clinical picture. Acta Med Iran. 2015;53(1):51-6.
- Kor DJ, Lingineni RK, Gajic O, Park PK, Blum JM, Hou PC, Hoth JJ, Anderson HL 3rd, Bajwa EK, Bartz RR, Adesanya A, Festic E, Gong MN, Carter RE, Talmor DS. Predicting risk of postoperative lung injury in high-risk surgical patients: a multicenter cohort study. Anesthesiology. 2014 May;120(5):1168-81. doi: 10.1097/ALN.0000000000000216.
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2017年7月1日
一次修了 (実際)
2017年9月30日
研究の完了 (実際)
2017年9月30日
試験登録日
最初に提出
2016年4月25日
QC基準を満たした最初の提出物
2016年4月29日
最初の投稿 (見積もり)
2016年5月3日
学習記録の更新
投稿された最後の更新 (実際)
2021年2月1日
QC基準を満たした最後の更新が送信されました
2021年1月28日
最終確認日
2019年12月1日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
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