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Risk Factors and Prediction Score of ARDS After Cardiac Surgery

28. januar 2021 opdateret af: Guangfa Zhu, Beijing Anzhen Hospital
Acute respiratory distress syndrome following cardiac surgery severely affects the prognosis of patients; the mortality is up to 40%. Although experience many years of research and exploration, the effective methods for the treatment of acute respiratory distress syndrome is still relatively limited at present, including lung protective mechanical ventilation respiratory support, fluid management, glucocorticoid and other integrated organ function maintenance measures. It is currently the research of acute respiratory distress syndrome aims at the early discovery and takes effective measures to prevent its occurrence, hoping to improve the prognosis of patients. According to risk factors is established through the analysis of lung injury score early warning system, the early identification of acute respiratory distress syndrome patients at high risk, before the occurrence of acute respiratory distress syndrome take corresponding preventive measures can effectively reduce the incidence rate and mortality. So far, domestic and foreign research on the establishment of acute respiratory distress syndrome scoring early warning system is less. Cardiac surgery has significant characteristics, type of operation, location, operation, intraoperative blood transfusion and oxygenation, postoperative factors, are likely to be the factors of acute respiratory distress syndrome. As far as investigators know, so far there are few specialized for acute respiratory distress syndrome predicting lung injury after cardiac surgery. This study will be completed after the implementation of individualized dynamic lung injury score evaluation of cardiac surgery patients, identification of high-risk acute respiratory distress syndrome patients, to assist clinicians in early decision, take preventive measures. This study will improve the prognosis of acute respiratory distress syndrome patients after cardiac surgery; it is of great significance to improve the level of intensive care after cardiac surgery.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

1333

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Kina
    • Beijing
      • Beijing, Beijing, Kina, 100029
        • Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Patients of cardiac surgery in Beijing Anzhen hospital

Beskrivelse

Inclusion Criteria:

  • Retrospective group: cardiac surgery patients accepted from Jan 2013 to Dec 2015
  • Prospective group: cardiac surgery patients accepted from 2017 January to December

Exclusion Criteria:

  • refused to participate in the study
  • age less than 18 years old
  • before operation performed mechanical ventilation
  • before operation underwent IABP treatment
  • before operation continuous renal replacement therapy
  • before operation undergoing in vitro membrane oxygenator treatment
  • before operation has the pulmonary imaging showed bilateral pulmonary diffuse exudation of interstitial pneumonia, pulmonary infection or respiratory failure
  • the major trauma, sepsis, aspiration, shock, acute heart failure
  • before operation diagnosed as malignant tumor
  • Incomplete data.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
ARDS
ARDS patients after cardiac surgery
Andet: no intervention
This is a clinical observational study, no intervention was included.
non-ARDS
non-ARDS patients after cardiac surgery
Andet: no intervention
This is a clinical observational study, no intervention was included.
propective group
patients of cardiac surgery including ARDS and non-ARDS patients
Andet: no intervention
This is a clinical observational study, no intervention was included.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
Tidsramme: up to 12months
up to 12months
The number of patients of cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
Tidsramme: up to 12months
up to 12months
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
Tidsramme: up to 12months
up to 12months
The number of patients of cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
Tidsramme: up to 12months
up to 12months
The number of diabetic patients in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The number of diabetic patients in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The number of chronic obstructive pulmonary disease patients in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The number of chronic obstructive pulmonary disease patients in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The type of operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The type of operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The body mass index in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The body mass index in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The heart function in ARDS group before operation.
Tidsramme: up to 1 month
up to 1 month
The heart function in non-ARDS group before operation.
Tidsramme: up to 1 month
up to 1 month
The oxygenation in ARDS group before operation.
Tidsramme: up to 1 month
up to 1 month
The oxygenation in non-ARDS group before operation.
Tidsramme: up to 1 month
up to 1 month
The drug taken by patients in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The drug taken by patients in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The nutrition situation of patients in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The nutrition situation of patients in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The process of operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The process of operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The blood transfusion of patients during operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The blood transfusion of patients during operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The oxygenation of patients during operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The oxygenation of patients during operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The drug taken by patients after operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The drug taken by patients after operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The oxygenation of patients after operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The oxygenation of patients after operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The situation of mechanical ventilation of patients after operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The situation of mechanical ventilation of patients after operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month

Sekundære resultatmål

Resultatmål
Tidsramme
The mortality of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
Tidsramme: up to 1months
up to 1months
The morbidity of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
Tidsramme: up to 1months
up to 1months

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Beijing Anzhen Hospital

Efterforskere

  • Studiestol: Guangfa Zhu, Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. juli 2017

Primær færdiggørelse (Faktiske)

30. september 2017

Studieafslutning (Faktiske)

30. september 2017

Datoer for studieregistrering

Først indsendt

25. april 2016

Først indsendt, der opfyldte QC-kriterier

29. april 2016

Først opslået (Skøn)

3. maj 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

1. februar 2021

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

28. januar 2021

Sidst verificeret

1. december 2019

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • Shoufa-2016-2-1052

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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Kliniske forsøg med no intervention

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