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Risk Factors and Prediction Score of ARDS After Cardiac Surgery

28. januar 2021 oppdatert av: Guangfa Zhu, Beijing Anzhen Hospital
Acute respiratory distress syndrome following cardiac surgery severely affects the prognosis of patients; the mortality is up to 40%. Although experience many years of research and exploration, the effective methods for the treatment of acute respiratory distress syndrome is still relatively limited at present, including lung protective mechanical ventilation respiratory support, fluid management, glucocorticoid and other integrated organ function maintenance measures. It is currently the research of acute respiratory distress syndrome aims at the early discovery and takes effective measures to prevent its occurrence, hoping to improve the prognosis of patients. According to risk factors is established through the analysis of lung injury score early warning system, the early identification of acute respiratory distress syndrome patients at high risk, before the occurrence of acute respiratory distress syndrome take corresponding preventive measures can effectively reduce the incidence rate and mortality. So far, domestic and foreign research on the establishment of acute respiratory distress syndrome scoring early warning system is less. Cardiac surgery has significant characteristics, type of operation, location, operation, intraoperative blood transfusion and oxygenation, postoperative factors, are likely to be the factors of acute respiratory distress syndrome. As far as investigators know, so far there are few specialized for acute respiratory distress syndrome predicting lung injury after cardiac surgery. This study will be completed after the implementation of individualized dynamic lung injury score evaluation of cardiac surgery patients, identification of high-risk acute respiratory distress syndrome patients, to assist clinicians in early decision, take preventive measures. This study will improve the prognosis of acute respiratory distress syndrome patients after cardiac surgery; it is of great significance to improve the level of intensive care after cardiac surgery.

Studieoversikt

Status

Fullført

Forhold

Intervensjon / Behandling

Studietype

Observasjonsmessig

Registrering (Faktiske)

1333

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Kina
    • Beijing
      • Beijing, Beijing, Kina, 100029
        • Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Barn
  • Voksen
  • Eldre voksen

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

Patients of cardiac surgery in Beijing Anzhen hospital

Beskrivelse

Inclusion Criteria:

  • Retrospective group: cardiac surgery patients accepted from Jan 2013 to Dec 2015
  • Prospective group: cardiac surgery patients accepted from 2017 January to December

Exclusion Criteria:

  • refused to participate in the study
  • age less than 18 years old
  • before operation performed mechanical ventilation
  • before operation underwent IABP treatment
  • before operation continuous renal replacement therapy
  • before operation undergoing in vitro membrane oxygenator treatment
  • before operation has the pulmonary imaging showed bilateral pulmonary diffuse exudation of interstitial pneumonia, pulmonary infection or respiratory failure
  • the major trauma, sepsis, aspiration, shock, acute heart failure
  • before operation diagnosed as malignant tumor
  • Incomplete data.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Kohorter og intervensjoner

Gruppe / Kohort
Intervensjon / Behandling
ARDS
ARDS patients after cardiac surgery
Annen: no intervention
This is a clinical observational study, no intervention was included.
non-ARDS
non-ARDS patients after cardiac surgery
Annen: no intervention
This is a clinical observational study, no intervention was included.
propective group
patients of cardiac surgery including ARDS and non-ARDS patients
Annen: no intervention
This is a clinical observational study, no intervention was included.

Hva måler studien?

Primære resultatmål

Resultatmål
Tidsramme
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
Tidsramme: up to 12months
up to 12months
The number of patients of cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
Tidsramme: up to 12months
up to 12months
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
Tidsramme: up to 12months
up to 12months
The number of patients of cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
Tidsramme: up to 12months
up to 12months
The number of diabetic patients in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The number of diabetic patients in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The number of chronic obstructive pulmonary disease patients in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The number of chronic obstructive pulmonary disease patients in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The type of operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The type of operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The body mass index in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The body mass index in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The heart function in ARDS group before operation.
Tidsramme: up to 1 month
up to 1 month
The heart function in non-ARDS group before operation.
Tidsramme: up to 1 month
up to 1 month
The oxygenation in ARDS group before operation.
Tidsramme: up to 1 month
up to 1 month
The oxygenation in non-ARDS group before operation.
Tidsramme: up to 1 month
up to 1 month
The drug taken by patients in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The drug taken by patients in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The nutrition situation of patients in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The nutrition situation of patients in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The process of operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The process of operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The blood transfusion of patients during operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The blood transfusion of patients during operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The oxygenation of patients during operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The oxygenation of patients during operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The drug taken by patients after operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The drug taken by patients after operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The oxygenation of patients after operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The oxygenation of patients after operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month
The situation of mechanical ventilation of patients after operation in ARDS group.
Tidsramme: up to 1 month
up to 1 month
The situation of mechanical ventilation of patients after operation in non-ARDS group.
Tidsramme: up to 1 month
up to 1 month

Sekundære resultatmål

Resultatmål
Tidsramme
The mortality of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
Tidsramme: up to 1months
up to 1months
The morbidity of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
Tidsramme: up to 1months
up to 1months

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Beijing Anzhen Hospital

Etterforskere

  • Studiestol: Guangfa Zhu, Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. juli 2017

Primær fullføring (Faktiske)

30. september 2017

Studiet fullført (Faktiske)

30. september 2017

Datoer for studieregistrering

Først innsendt

25. april 2016

Først innsendt som oppfylte QC-kriteriene

29. april 2016

Først lagt ut (Anslag)

3. mai 2016

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

1. februar 2021

Siste oppdatering sendt inn som oppfylte QC-kriteriene

28. januar 2021

Sist bekreftet

1. desember 2019

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • Shoufa-2016-2-1052

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