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Risk Factors and Prediction Score of ARDS After Cardiac Surgery

28 de janeiro de 2021 atualizado por: Guangfa Zhu, Beijing Anzhen Hospital
Acute respiratory distress syndrome following cardiac surgery severely affects the prognosis of patients; the mortality is up to 40%. Although experience many years of research and exploration, the effective methods for the treatment of acute respiratory distress syndrome is still relatively limited at present, including lung protective mechanical ventilation respiratory support, fluid management, glucocorticoid and other integrated organ function maintenance measures. It is currently the research of acute respiratory distress syndrome aims at the early discovery and takes effective measures to prevent its occurrence, hoping to improve the prognosis of patients. According to risk factors is established through the analysis of lung injury score early warning system, the early identification of acute respiratory distress syndrome patients at high risk, before the occurrence of acute respiratory distress syndrome take corresponding preventive measures can effectively reduce the incidence rate and mortality. So far, domestic and foreign research on the establishment of acute respiratory distress syndrome scoring early warning system is less. Cardiac surgery has significant characteristics, type of operation, location, operation, intraoperative blood transfusion and oxygenation, postoperative factors, are likely to be the factors of acute respiratory distress syndrome. As far as investigators know, so far there are few specialized for acute respiratory distress syndrome predicting lung injury after cardiac surgery. This study will be completed after the implementation of individualized dynamic lung injury score evaluation of cardiac surgery patients, identification of high-risk acute respiratory distress syndrome patients, to assist clinicians in early decision, take preventive measures. This study will improve the prognosis of acute respiratory distress syndrome patients after cardiac surgery; it is of great significance to improve the level of intensive care after cardiac surgery.

Visão geral do estudo

Status

Concluído

Condições

Intervenção / Tratamento

Tipo de estudo

Observacional

Inscrição (Real)

1333

Contactos e Locais

Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.

Locais de estudo

  • China
    • Beijing
      • Beijing, Beijing, China, 100029
        • Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

Critérios de participação

Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.

Critérios de elegibilidade

Idades elegíveis para estudo

  • Filho
  • Adulto
  • Adulto mais velho

Aceita Voluntários Saudáveis

Não

Gêneros Elegíveis para o Estudo

Tudo

Método de amostragem

Amostra Não Probabilística

População do estudo

Patients of cardiac surgery in Beijing Anzhen hospital

Descrição

Inclusion Criteria:

  • Retrospective group: cardiac surgery patients accepted from Jan 2013 to Dec 2015
  • Prospective group: cardiac surgery patients accepted from 2017 January to December

Exclusion Criteria:

  • refused to participate in the study
  • age less than 18 years old
  • before operation performed mechanical ventilation
  • before operation underwent IABP treatment
  • before operation continuous renal replacement therapy
  • before operation undergoing in vitro membrane oxygenator treatment
  • before operation has the pulmonary imaging showed bilateral pulmonary diffuse exudation of interstitial pneumonia, pulmonary infection or respiratory failure
  • the major trauma, sepsis, aspiration, shock, acute heart failure
  • before operation diagnosed as malignant tumor
  • Incomplete data.

Plano de estudo

Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.

Como o estudo é projetado?

Detalhes do projeto

Coortes e Intervenções

Grupo / Coorte
Intervenção / Tratamento
ARDS
ARDS patients after cardiac surgery
Outro: no intervention
This is a clinical observational study, no intervention was included.
non-ARDS
non-ARDS patients after cardiac surgery
Outro: no intervention
This is a clinical observational study, no intervention was included.
propective group
patients of cardiac surgery including ARDS and non-ARDS patients
Outro: no intervention
This is a clinical observational study, no intervention was included.

O que o estudo está medindo?

Medidas de resultados primários

Medida de resultado
Prazo
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
Prazo: up to 12months
up to 12months
The number of patients of cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
Prazo: up to 12months
up to 12months
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
Prazo: up to 12months
up to 12months
The number of patients of cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
Prazo: up to 12months
up to 12months
The number of diabetic patients in ARDS group.
Prazo: up to 1 month
up to 1 month
The number of diabetic patients in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The number of chronic obstructive pulmonary disease patients in ARDS group.
Prazo: up to 1 month
up to 1 month
The number of chronic obstructive pulmonary disease patients in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The type of operation in ARDS group.
Prazo: up to 1 month
up to 1 month
The type of operation in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The body mass index in ARDS group.
Prazo: up to 1 month
up to 1 month
The body mass index in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The heart function in ARDS group before operation.
Prazo: up to 1 month
up to 1 month
The heart function in non-ARDS group before operation.
Prazo: up to 1 month
up to 1 month
The oxygenation in ARDS group before operation.
Prazo: up to 1 month
up to 1 month
The oxygenation in non-ARDS group before operation.
Prazo: up to 1 month
up to 1 month
The drug taken by patients in ARDS group.
Prazo: up to 1 month
up to 1 month
The drug taken by patients in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The nutrition situation of patients in ARDS group.
Prazo: up to 1 month
up to 1 month
The nutrition situation of patients in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The process of operation in ARDS group.
Prazo: up to 1 month
up to 1 month
The process of operation in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The blood transfusion of patients during operation in ARDS group.
Prazo: up to 1 month
up to 1 month
The blood transfusion of patients during operation in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The oxygenation of patients during operation in ARDS group.
Prazo: up to 1 month
up to 1 month
The oxygenation of patients during operation in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The drug taken by patients after operation in ARDS group.
Prazo: up to 1 month
up to 1 month
The drug taken by patients after operation in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The oxygenation of patients after operation in ARDS group.
Prazo: up to 1 month
up to 1 month
The oxygenation of patients after operation in non-ARDS group.
Prazo: up to 1 month
up to 1 month
The situation of mechanical ventilation of patients after operation in ARDS group.
Prazo: up to 1 month
up to 1 month
The situation of mechanical ventilation of patients after operation in non-ARDS group.
Prazo: up to 1 month
up to 1 month

Medidas de resultados secundários

Medida de resultado
Prazo
The mortality of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
Prazo: up to 1months
up to 1months
The morbidity of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
Prazo: up to 1months
up to 1months

Colaboradores e Investigadores

É aqui que você encontrará pessoas e organizações envolvidas com este estudo.

Patrocinador

Beijing Anzhen Hospital

Investigadores

  • Cadeira de estudo: Guangfa Zhu, Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

Publicações e links úteis

A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.

Publicações Gerais

Datas de registro do estudo

Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados ​​pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.

Datas Principais do Estudo

Início do estudo (Real)

1 de julho de 2017

Conclusão Primária (Real)

30 de setembro de 2017

Conclusão do estudo (Real)

30 de setembro de 2017

Datas de inscrição no estudo

Enviado pela primeira vez

25 de abril de 2016

Enviado pela primeira vez que atendeu aos critérios de CQ

29 de abril de 2016

Primeira postagem (Estimativa)

3 de maio de 2016

Atualizações de registro de estudo

Última Atualização Postada (Real)

1 de fevereiro de 2021

Última atualização enviada que atendeu aos critérios de controle de qualidade

28 de janeiro de 2021

Última verificação

1 de dezembro de 2019

Mais Informações

Termos relacionados a este estudo

Termos MeSH relevantes adicionais

Outros números de identificação do estudo

  • Shoufa-2016-2-1052

Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .

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