Investigation of Clinical Feature and Brain Function in Narcoleptic Patients
Feature of Polysomnography and Cerebral Metabolism and Function in Narcolepsy With/Without RBD and Control Subject
研究概览
详细说明
Polysomnographic (PSG) work-up one night to record nocturnal sleep condition in narcolepsy with /without RBD and control subjects including sleep macrostructure, occurrence of sleep onset rapid eye movement period(SOREMP), sleep stages distribution, and sleep arousle and leg movement and apnea hyponea index would be calculated.
Functional magnetic resonance imaging (fMRI) has been used in human to nonivasiverlyn investigate the neural mechanisms. This technique also apply to measures the variations in brain perfusion, structure and morphology in narcolepsy patients by assessing the blood oxygen level-dependent (BOLD) signal diffusion tensor imaging (DTI and voxel-based morphometry(VBM)
This study compare the feature of PSG and fMRI between narcolepsy with RBD, narcolepsy without RBD, control subject to evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD.
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名：Guoyan Chen, MD
- 电话号码：86-02984717792
- 邮箱：chenguoyan29@126.com
研究联系人备份
- 姓名：Wen Wang, PhD
- 电话号码：86-02984778689
- 邮箱：wangwen@fmmu.edu.cn
学习地点
-
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Shan
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Xi'an、Shan、中国、710000
- 招聘中
- Tangdu Hospital
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接触：
- Guoyan Chen, MD
- 电话号码：86-02984717792
- 邮箱：chenguoyan29@126.com
-
接触：
- Wen Wang, PhD
- 电话号码：86-029778689
- 邮箱：wangwen@fmmu.edu.cn
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Narcolepsy meet to the international classification of sleep disorder,3rd edition (ICSD-3) , and RBD meet to the minimal diagnostic criteria according to the international Classification of Sleep, control subjects .
Exclusion Criteria:
History of heart disease History of central nervous system organic psychosis AHI>15次/h History of alcohol dependence and drug abuse
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
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Narcolepsy with RBD & Control
Narcolepsy with REM sleep disorder lable(20) and Control subjects lable(20)
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Narcolepsy with /without RBD
Narcolepsy with REM sleep disorder lable(20) and Narcolepsy without REM sleep disorderlable (20)
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
video-polysomnographic(PSG)
大体时间：up to 100 weeks
|
video-PSG monitor sleep from 9:00pm to 6:00am
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up to 100 weeks
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
multiple sleep latency test (MSLT)
大体时间：up to 100 weeks
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MSLT in the next day of PSG record daytime sleepiness
|
up to 100 weeks
|
|
functional magnetic resonance imaging (fMRI)
大体时间：up to 100 weeks
|
All narcolepsy with or withoutRBD accepts fMRI
|
up to 100 weeks
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- TDLL-201601-08
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