Obesity and Mortality of Critically Ill Patients With COVID-19 (COV-OB-ICU)
Obesity as a Risk Factor for Mortality of Critically Ill Patients With Coronavirus Disease 2019 (COVID-19): a Cohort Study of the First Wave in Nancy, France
Disproportionate impact of COVID-19 in patients with obesity is now well established.
Obesity is associated with severe forms of COVID-19 and may be a risk factor of intensive care unit (ICU) admission. Obesity is associated with COVID-19 related hospital death in a large United Kingdom cohort study. However, there is a gap of knowledge on assessment of outcomes such as severity of Acute Respiratory Distress syndrome (ARDS), duration of hospitalisation and mortality in ICU. Moreover, an obesity survival paradox has been observed in patients with ARDS. This raises the question whether the obesity paradox has been broken by COVID-19.
The investigators aim to explore risk factors of in-ICU death for patient with COVID-19, including obesity and other chronic diseases and to describe the clinical course and outcomes, including the management of acute respiratory failure and other intensive care management.
研究概览
地位
详细说明
The investigators aim to report ICU mortality for patients according to BMI category and to describe the detailed ICU clinical course of illness :
- Risk factors for ICU mortality : age, sex, baseline comorbidities
- Causes of death
- Risk factors for use of non invasive mechanical ventilation
- Non-fatal outcomes
- Ventilator-free days
- ICU length of stay.
研究类型
注册 (实际的)
联系人和位置
学习地点
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-
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Vandœuvre-lès-Nancy、法国、54511
- Centre hospitalo-universitaire régional de Nancy
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Adult patients with COVID-19 pneumonia admitted to ICUs between February 27th and April 18th 2020.
- Infection confirmed by reverse transcriptase polymerase chain reaction assay or radiologically by chest computed tomography scan
Exclusion Criteria:
- No weight or height measurement available in the medical files
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
|
Normal weight
BMI < 25 kg/m2
|
|
Overweight
BMI : 25 - 29.9 kg/m2
|
|
Moderate obesity
BMI : 30 - 39.9 kg/m2
|
|
Severe obesity
BMI : > or = 40 kg/m2
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
ICU mortality
大体时间：through study completion, an average of 14 days
|
number of fatal cases
|
through study completion, an average of 14 days
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Invasive mechanical ventilation
大体时间：through study completion, an average of 14 days
|
number of patients with invasive mechanical ventilation
|
through study completion, an average of 14 days
|
|
In-hospital mortality
大体时间：through study completion, an average of 21 days
|
number of fatal cases
|
through study completion, an average of 21 days
|
合作者和调查者
调查人员
- 首席研究员：Olivier Ziegler, PU-PH、CHRU of Nancy
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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