National, Multi-center, Prospective, and Retrospective Cohort Study. (REGION)
Russian Registry of Acute Myocardial Infarction
National, multi-center, observational, prospective, and retrospective cohort study. The study does not provide for intervention in routine clinical practice.
Key goals:
• Obtaining real-world evidence on the diagnosis and treatment of AIM in Russian hospitals, including both long- and short-term findings and outcomes (i.e. during hospitalization,
and 6-12 months after the diagnosis establishment).
- Evaluation of the applied approaches to the management of AIM patients for compliance with the clinical recommendations across various hospitals, with a breakdown by equipment status;
- Assessment of patients' treatment adherence after 6 and 12 months.
The expected project duration is 3 years. The study subjects will be recruited during the first 24 months unless the investigators decide to terminate or extend the study period. The period of observation for each patient is 6 to 12 months. The project involves retrospective and prospective collection of information from medical records. All patient data shall be recorded by the Investigator into an approved electronic case report form (eCRF).
Recruitment period: 2020-2022. Expected number of subjects: 10,000.
研究概览
地位
条件
详细说明
The Russian Registry of Acute Myocardial Infarction study is an independent study initiated by the investigators;
The partner inpatient hospitals will provide data on every patient with known acute myocardial infarction (I21) admitted between days 1 and 10 of each month during the recruitment period.The Russian Registry of Acute Myocardial Infarction study is an independent study initiated by the investigators;
For every engaged hospital (medical center) the investigators will designate a 2-3 person task team, including a Team Leader;
The participants shall be kept informed and coordinated via email and messengers. The website of the Russian Society of Emergency Cardiology.
The study will be hosted by the CRM Quinta® platform.
Administration, data entry monitoring, and statistical processing will be carried out by Aston Consulting (a certified personal data operator.)
AO Aston Consulting has a license for storage and processing of personal data in accordance with the applicable legislation.
PATIENTS.
INCLUSION CRITERIA
1. Diagnosed acute ST-elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI) (ICD 10 I21 ); the diagnosis is established based on the Fourth Universal Definition of Myocardial Infarction Guidelines 2018 .
EXCLUSION CRITERIA
1. A patient or his/her legal representative did not sign IC.
STUDY ASSESSMENTS
The following information will be collected and entered into CRF: Full name
Residential address
Phone number of patients or their legal representatives' Demographic profile. Weight, height
Social status (education, job title, occupation status)
Co-morbidities
Clinical signs and symptoms
Drug therapy.
Clinical outcomes during the hospital stay.
Drug therapy and clinical outcomes in 6 and 12 months after the diagnosis establishment.
Hospitals wishing to join the study must contact any of the project coordinators and complete the Participation questionnaire (Appendix 4).
The Registry enrolment process starts in 2020 and will continue for 24 months. The hospitals that will not be able to start the enrolment in 2020 will have the chance to do it before December 31, 2022, and perform the follow-up monitoring for the next 12 months.
At the moment of the enrolment, the patient's data are to be entered into the online database. Any new data that might appear during the hospital stay will be successively or immediately entered into the database at the moment of the patient's death/discharge. The data received during an in-person or a phone contact 6 or 12 months after the enrolment will also be entered into the database.
Shall the initiators have any questions regarding the entered data, they will ask the participants to elaborate, clarify, or correct the data.
If the patient dies before the enrolment to the study, his/her data shall be entered into the database retrospectively.
The patients (or their legal representatives) enrolled to the Registry must be kept informed about the inclusion in this observational program and give their written consent for participation (patients who died or are otherwise unable to sign the consent to the processing of personal data will be enrolled on a de-identified basis.)
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名:Shakhnovich
- 电话号码:+7 9037992718
- 邮箱:shakhnovich@mail.ru
学习地点
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Moscow、俄罗斯联邦、121551
- 招聘中
- Federal State Budgetary Institution NATIONAL MEDICAL CENTER CARDIOLOGY RESEARCH CENTER Ministry of Health of the Russian Federation
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接触:
- Shakhnovich
- 电话号码:+79037992718
- 邮箱:shakhnovich@mail.ru
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- 1. Diagnosed acute ST-elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI) (ICD 10 I21); the diagnosis is established based on the Fourth Universal Definition of Myocardial Infarction Guidelines 2018 .
The diagnosed patient was admitted to the hospital between days 1 and 10 of the current mont.
Exclusion Criteria:
1. A patient or his/her legal representative did not sign the IC.
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学习计划
研究是如何设计的?
设计细节
- 观测模型:队列
- 时间观点:横截面
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Monitoring of the patient
大体时间:12 monthes
|
Recording of all events that occur with the patient for 12 months from the moment of diagnosis Acute myocardial infarction : repeated heart attack, change of therapy, complications from the cardiovascular system, death
|
12 monthes
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Frequency of the following episodes 2. The proportion of patients who continue taking statins, antiplatelets, and drugs from other groups 6 months or 1 year post-discharge.
大体时间:12 monthes
|
Record the f- recurrent MI
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12 monthes
|
合作者和调查者
调查人员
- 首席研究员:Pevzner、Myasnikov Institute of Clinical Cardiology
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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