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Early COPD for China Pulmonary Health Study Stage II (EC-CPHS)

2021年8月29日更新者：Chen Wang、China-Japan Friendship Hospital

A Cohort Study of Early Chronic Obstructive Pulmonary Disease for China Pulmonary Health Study Stage II

Discovery of the pathogenesis and targets in the progression of early chronic obstructive pulmonary disease

研究概览

地位

招聘中

条件

阻塞性肺病

详细说明

This project is aimed to investigate and explore the heterogeneity during the progression of Chronic Obstructive Pulmonary Disease (COPD) in the early stage, utilizing the large-scale population cohort databases (including "China Pulmonary Health study", "The Cohort Study for Chronic Obstructive Pulmonary Disease in China" and "Acute Exacerbation of COPD Patient Registry in China" ), biological sample libraries(including blood, sputum, expiratory air, bronchoalveolar lavage fluid(BALF), and lung tissue from COPD patients with different stages and phenotypes), and multi-omics sequencing (including scRNA-seq, metabolomics, proteomics, and metagenome). We propose to establish a new standard for COPD stages and subtypes. By analyzing and mining the multi-omics data, it is expected to illustrate the association between clinical phenotype and molecular, cellular and tissue heterogeneities, thus reveal biomarkers related to the progression, clinical phenotypes, and prognosis of early-stage COPD disease.In addition, we will construct different types and stages of COPD animal models for further mechanism studies, such as the different pathogenic factors, innate and adaptive immunity, and the airway microbial ecosystem, so that we can discovered more potential therapeutic target for early-stage COPD. This project can bring a new insight and scientific evidence for COPD treatment.

研究类型

观察性的

注册 (预期的)

400

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

姓名：Chen Wang
电话号码：+86 010 69156477
邮箱：cyh-birm@263.net

学习地点

中国
- - Beijing、中国
    - 招聘中
    - Peking University Third Hospital
    - 接触：
      
      Yahong Chen
  - Beijing、中国
    - 招聘中
    - China-Japan Friendship Hospital
    - 接触：
      
      Ting Yang
  - Beijing、中国
    - 招聘中
    - Capital Medical University
  - Beijing、中国
    - 招聘中
    - Institue of Basic Medical Sciences Chinese Academy of Medical Sciences
    - 接触：
      
      Jing Wang
  - Shanghai、中国
    - 招聘中
    - Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
    - 接触：
      
      Weining Xiong
- Zhejiang
  - Hangzhou、Zhejiang、中国
    - 招聘中
    - Second Affiliated Hospital of Zhejiang University School of Medicine

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年至 50年 (成人)

接受健康志愿者

是的

有资格学习的性别

全部

取样方法

非概率样本

研究人群

early COPD patients and healthy controls

描述

Inclusion Criteria:

younger than 50 years
smoking more than 10 pack-years
early airflow limitation(post-bronchodilator FEV1/FVC< lower limit of normal)

Exclusion Criteria:

cancer
other respiratory diseases
mental illness

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

团体/队列数

队列和干预

团体/队列
early COPD patients younger than 50 years with 10 or more pack-years smoking history and any of these abnormalities: 1) early airflow limitation (post-bronchodilator forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC) < lower limit of normal), 2) compatible CT abnormalities, 3) rapid decline in FEV1 (≥60 ml/yr).
Healthy people healthy without any disabling, physical, neurological, or mental disease and were excluded living in a nursing home.

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
FEV1 annual decline in clinical practice 大体时间：2021.1-2024.12	FEV1 measured by portable spirometry can reflect the progression of early COPD.	2021.1-2024.12

次要结果测量

结果测量	措施说明	大体时间
dyspnea symptoms 大体时间：2021.1-2024.12	Severity of dyspnea is positively correlated with COPD severity.	2021.1-2024.12
frequency of COPD acute exacerbation 大体时间：2021.1-2024.12	The frequency of COPD acute exacerbation refers to the number of acute exacerbations per year.	2021.1-2024.12
chest imaging changes 大体时间：2021.1-2024.12	Emphysema and obstruction in small airway will be evaluated by chest computed tomography(CT).	2021.1-2024.12
systemic complications 大体时间：2021.1-2024.12	Whether there are systemic complications is related to the prognosis of patients.	2021.1-2024.12

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

China-Japan Friendship Hospital

合作者

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Peking University Third Hospital

Second Affiliated Hospital, School of Medicine, Zhejiang University

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Capital Medical University

调查人员

首席研究员：Yahong Chen、Peking University Third Hospital
学习椅：Chen Wang、Institue of Basic Medical Sciences Chinese Academy of Medical Sciences
首席研究员：Ting Yang、China-Japan Friendship Hospital
首席研究员：Jing Wang、Institue of Basic Medical Sciences Chinese Academy of Medical Sciences
首席研究员：Huahao Shen、Second Affiliated Hospital of Zhejiang University School of Medicine
首席研究员：Wei Wang、Capital Medical University
首席研究员：Weining Xiong、Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2021年1月1日

初级完成 (预期的)

2025年1月1日

研究完成 (预期的)

2025年12月1日

研究注册日期

首次提交

2021年6月3日

首先提交符合 QC 标准的

2021年8月29日

首次发布 (实际的)

2021年8月31日

研究记录更新

最后更新发布 (实际的)