Short- and Long-term Health Adverse Outcomes Associated With Nutrition Disorders and Nutrition Related Conditions in Hospitalized Older People
Malnutrition is associated with health adverse outcomes such as higher risk of mobility disability, falls and, fractures and higher mortality. Malnutrition had been defined as "a state resulting from lack of intake or uptake of nutrition that leads to altered body composition (decreased fat free mass) and body cell mass leading to diminished physical and mental function and impaired clinical outcome from disease". In 2018, the European Society for Clinical Nutrition and Metabolism (ESPEN) revisited nutrition and nutrition-related conditions definitions in the ESPEN guidelines on definitions and terminology of clinical nutrition based on the findings of the last decades. Nutrition disorders and nutrition related conditions were divided in 5 categories: Malnutrition/undernutrition, sarcopenia and frailty, overweight and obesity, micronutrients abnormalities, and refeeding syndrome. The definition of malnutrition based on the Global Leadership Initiative on Malnutrition (GLIM) criteria is globally accepted by de scientific community since this was launched in 2019. The presence of at least one phenotypic (i.e., nonintentional weight loss, low body mass index or low muscle mass) and one etiologic criterion (i.e., reduced food intake or inflammation) were required to define malnutrition.
Malnutrition is a common pathological condition in older adults that can further influence and aggravate health-related muscle decline. Sarcopenia is known as a natural progressive decline in skeletal muscles occurring with age, with an age-related decline in muscle strength. According to the criteria published in 2019 by the European Working Group on Sarcopenia in Older People (EWGSOP2), this process is defined by the presence of low muscle strength and low muscle mass.
Patients in acute care are likely to present higher stay and risk of mortality. However, the mortality have rarely been applied in acute care, due to difficulties to administer Dual X-ray Absorptiometry (DXA), the gold standard method for muscle mass in acute care. Pragmatic approaches to assess nutrition and nutrition-related condition are urgently needed to provide better quality of care in clinical practice in geriatric medicine.
The primary objective of this study is to determine the impact of nutrition disorders and nutrition-related conditions at baseline (admission in hospitalization) on the all-causes mortality risk in hospitalized older people.
Secondarily, this study evaluates their impact on other health adverse outcomes: falls, fractures, rehospitalization, institutionalization, all-cause admission in intensive care, length of hospital stay, length of ventilation and USI stay.
Finally, the diagnostic performance indicators of the Mini Nutritional Assessment (MNA-SF) and the Geriatric Nutritional Risk Index (GNRI) for malnutrition assessment following the GLIM criteria were calculated.
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名:Marie Claessens, MD
- 电话号码:32472488182
- 邮箱:marie.claessens@chu-brugmann.be
学习地点
-
-
-
Brussels、比利时
- 招聘中
- CHU Brugmann
-
接触:
- Marie Claessens, MD
- 电话号码:32472488182
- 邮箱:marie.claessens@chu-brugmann.be
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Patients aged ≥60 and over admitted to the geriatric healthcare unit and/or the COVID-19 unit of the CHU Brugmann Hospital, between 01/01/2016 and 12/10/2021.
- Patients who had the assessment of nutrition disorders and/or nutrition related conditions available during their hospital admission.
Exclusion Criteria:
- No exclusion criteria based on demographical or medical data were applied.
学习计划
研究是如何设计的?
设计细节
- 观测模型:队列
- 时间观点:追溯
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
All-cause mortality
大体时间:From 2016 till 2021
|
Vital status (death/alive)
|
From 2016 till 2021
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Falls
大体时间:From 2016 till 2021
|
Falls (yes/no)
|
From 2016 till 2021
|
Fractures of upper and lower limbs and/or hip and/or vertebrae
大体时间:From 2016 till 2021
|
Fractures of upper and lower limbs and/or hip and/or vertebrae (yes/no)
|
From 2016 till 2021
|
Re-hospitalization
大体时间:From 2016 till 2021
|
Unplanned readmission in hospital (yes/no)
|
From 2016 till 2021
|
Institutionalization
大体时间:From 2016 till 2021
|
Institutionalization (yes/no)
|
From 2016 till 2021
|
All-cause admission in intensive care
大体时间:From 2016 till 2021
|
All-cause admission in intensive care (yes/no)
|
From 2016 till 2021
|
Mechanical ventilation
大体时间:From 2016 till 2021
|
Mechanical ventilation (yes/no)
|
From 2016 till 2021
|
Length of hospital stay time from admission to discharge
大体时间:From 2016 till 2021
|
Length of hospital stay time from admission to discharge
|
From 2016 till 2021
|
Sensitivity
大体时间:From 2016 till 2021
|
Diagnostic performance indicators: the ability of a screening test to identify malnourished patients according to the GLIM criteria.
|
From 2016 till 2021
|
Specificity
大体时间:From 2016 till 2021
|
Diagnostic performance indicators: the ability of a screening test to identify non-malnourished patients according to the GLIM criteria.
|
From 2016 till 2021
|
Positive predictive value (PPV)
大体时间:From 2016 till 2021
|
Positive predictive value is the proportion of positive screening test results that are true positives for the diagnosis of malnutrition according to GLIM criteria.
|
From 2016 till 2021
|
Negative predictive value (NPV)
大体时间:From 2016 till 2021
|
Negative predictive value (NPV) is the proportion of negative screening test results that are true negative for the diagnosis of malnutrition according to the GLIM criteria.
|
From 2016 till 2021
|
Area under the ROC curve (AUC)
大体时间:From 2016 till 2021
|
A measure of the precision of a quantitative diagnostic test, which gives equal weight to sensitivity and specificity.
|
From 2016 till 2021
|
合作者和调查者
调查人员
- 首席研究员:Marie Claessens、CHU Brugmann
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- CHUB-Nutrition disorders
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)?
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.