此页面是自动翻译的，不保证翻译的准确性。请参阅 英文版 对于源文本。

Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise

2026年8月10日 更新者：ESM Technologies, LLC

Effects of NEM® Brand Eggshell Membrane and curQ+® Brand Highly Absorbable Curcumin Supplementation, Alone or in Combination, on Recovery From Intense Exercise in Recreationally Active Men.

Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients affects recovery from intense exercise.

研究概览

地位

招聘中

条件

干预/治疗

详细说明

Eggshell membrane (EM) is derived from the inner fibrous layer of eggs that contain a number of proteins and Types I, V, and X collagen and sulfur containing amino acids (i.e., e.g., methionine, cysteine), glycosaminoglycans (e.g., hyaluronic acid, dermatan sulfate, chondroitin sulfate) that are found in synovium, cartilage, ligaments, and tendons of human joint tissue. Initial studies have shown that EM supplementation reduces inflammation and perception of pain while improving markers of joint health in individuals with osteoarthritis. Curcumin (Curcuma longa) is a member of the ginger family (Zingiberaceae) that contains polyphenols that have anti-inflammatory properties. Studies show that curcumin (Curc) can reduce inflammation related to osteoarthritis, exercise, concussion and traumatic brain injury. Theoretically, EM and Curc supplementation prior to intense exercise may reduce inflammation, perceptions of muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients (NEM® brand eggshell membrane and curQ+® brand highly absorbable curcumin) separately and in combination affects recovery from intense exercise in recreationally active men.

研究类型

介入性

注册 (估计的)

60

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

  • 姓名：Richard B. Kreider, Ph.D.
  • 电话号码：(979) 458-1498
  • 邮箱：rbkreider@tamu.edu

研究联系人备份

  • 姓名：Christopher Rasmussen, M.S.
  • 电话号码：(979) 458-1498
  • 邮箱：crasmussen@tamu.edu

学习地点

  • 美国
    • Texas
      • College Station、Texas、美国、77843
        • 招聘中
        • Exercise & Sport Nutrition Lab - Texas A&M University
        • 接触：
        • 接触：
        • 首席研究员：
          • Richard B. Kreider, Ph.D.

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人

接受健康志愿者

是的

描述

Inclusion Criteria:

  • Age 18 to 40 at the time of consent.
  • Healthy and recreationally active.
  • Ability to comply with study procedures.
  • Agree to refrain from alcohol intake and use of non-steroidal anti-inflammatory (NSAIDS), aspirin, and other over-the-counter pain medications for 48 hours prior to and after completion of each testing session.

Exclusion Criteria:

  • No recent history of exercise training
  • An orthopedic limitation that would prevent the ability to perform the exercise intervention.
  • Participants who currently smoke cigarettes.
  • Known allergies to eggs, sulfur, or curcumin.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：预防
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：四人间

武器和干预

参与者组/臂
干预/治疗
实验性的：Active, EM
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.
膳食补充剂：NEM® brand eggshell membrane powder
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.
膳食补充剂：Curc Placebo
2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.
实验性的：Active, curc
2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
膳食补充剂：curQ+® brand highly absorbable curcumin
2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
膳食补充剂：EM Placebo
500 mg/day of psyllium husk fiber powder in a single #0 capsule.
安慰剂比较：Placebo
500 mg/day of psyllium husk fiber powder in a single #0 capsule PLUS 2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.
膳食补充剂：Curc Placebo
2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.
膳食补充剂：EM Placebo
500 mg/day of psyllium husk fiber powder in a single #0 capsule.
实验性的：Active, EM+Curc
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule PLUS 2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
膳食补充剂：NEM® plus curQ+® combination
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule PLUS 2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
VAS Muscle Soreness Rating
大体时间：2 weeks
Changes in Visual Analog Scale (VAS) ratings of muscle soreness (rated from zero to 100 mm) from baseline following intense exercise. The higher the rating, the more muscle soreness so negative changes in VAS would equate to improvement.
2 weeks

次要结果测量

结果测量
措施说明
大体时间
Urinary CTX-II
大体时间：2 weeks
Changes in urinary CTX-II biomarker from baseline following intense exercise.
2 weeks
Muscle Damage
大体时间：2 weeks
Changes in markers of muscle enzyme efflux/damage (CK, LDH) from baseline following intense exercise.
2 weeks
Exercise Performance
大体时间：2 weeks
Changes in exercise performance (strength, muscular endurance, peak aerobic capacity) from baseline following intense exercise.
2 weeks
Inflammation Biomarkers
大体时间：2 weeks
Changes in markers of inflammation (TNFα, interleukin (IL) cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10) from baseline following intense exercise.
2 weeks

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

ESM Technologies, LLC

合作者

Exercise & Sport Nutrition Lab, Texas A&M University

调查人员

  • 研究主任：Kevin J. Ruff, Ph.D.、ESM Technologies, LLC
  • 首席研究员：Richard B. Kreider, Ph.D.、Exercise & Sport Nutrition Lab, Texas A&M University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2026年2月1日

初级完成 (估计的)

2026年10月15日

研究完成 (估计的)

2026年12月31日

研究注册日期

首次提交

2026年7月30日

首先提交符合 QC 标准的

2026年8月10日

首次发布 (实际的)

2026年8月14日

研究记录更新

最后更新发布 (实际的)

2026年8月14日

上次提交的符合 QC 标准的更新

2026年8月10日

最后验证

2026年8月1日

更多信息

与本研究相关的术语

关键字

其他研究编号

  • STUDY2025-0899

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

订阅