Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise
10. august 2026 opdateret af: ESM Technologies, LLC
Effects of NEM® Brand Eggshell Membrane and curQ+® Brand Highly Absorbable Curcumin Supplementation, Alone or in Combination, on Recovery From Intense Exercise in Recreationally Active Men.
Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery.
This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients affects recovery from intense exercise.
Studieoversigt
Status
Rekruttering
Betingelser
Detaljeret beskrivelse
Eggshell membrane (EM) is derived from the inner fibrous layer of eggs that contain a number of proteins and Types I, V, and X collagen and sulfur containing amino acids (i.e., e.g., methionine, cysteine), glycosaminoglycans (e.g., hyaluronic acid, dermatan sulfate, chondroitin sulfate) that are found in synovium, cartilage, ligaments, and tendons of human joint tissue.
Initial studies have shown that EM supplementation reduces inflammation and perception of pain while improving markers of joint health in individuals with osteoarthritis.
Curcumin (Curcuma longa) is a member of the ginger family (Zingiberaceae) that contains polyphenols that have anti-inflammatory properties.
Studies show that curcumin (Curc) can reduce inflammation related to osteoarthritis, exercise, concussion and traumatic brain injury.
Theoretically, EM and Curc supplementation prior to intense exercise may reduce inflammation, perceptions of muscle and joint pain, and promote recovery.
This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients (NEM® brand eggshell membrane and curQ+® brand highly absorbable curcumin) separately and in combination affects recovery from intense exercise in recreationally active men.
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
60
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Richard B. Kreider, Ph.D.
- Telefonnummer: (979) 458-1498
- E-mail: rbkreider@tamu.edu
Undersøgelse Kontakt Backup
- Navn: Christopher Rasmussen, M.S.
- Telefonnummer: (979) 458-1498
- E-mail: crasmussen@tamu.edu
Studiesteder
-
-
Texas
-
College Station, Texas, Forenede Stater, 77843
- Rekruttering
- Exercise & Sport Nutrition Lab - Texas A&M University
-
Kontakt:
- Richard B. Kreider, Ph.D.
- Telefonnummer: (979) 458-1498
- E-mail: rbkreider@tamu.edu
-
Kontakt:
- Christopher Rasmussen, M.S.
- Telefonnummer: (979) 458-1498
- E-mail: crasmussen@tamu.edu
-
Ledende efterforsker:
- Richard B. Kreider, Ph.D.
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
Tager imod sunde frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Age 18 to 40 at the time of consent.
- Healthy and recreationally active.
- Ability to comply with study procedures.
- Agree to refrain from alcohol intake and use of non-steroidal anti-inflammatory (NSAIDS), aspirin, and other over-the-counter pain medications for 48 hours prior to and after completion of each testing session.
Exclusion Criteria:
- No recent history of exercise training
- An orthopedic limitation that would prevent the ability to perform the exercise intervention.
- Participants who currently smoke cigarettes.
- Known allergies to eggs, sulfur, or curcumin.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Forebyggelse
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Firedobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Active, EM
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.
|
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.
2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.
|
|
Eksperimentel: Active, curc
2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
|
2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
500 mg/day of psyllium husk fiber powder in a single #0 capsule.
|
|
Placebo komparator: Placebo
500 mg/day of psyllium husk fiber powder in a single #0 capsule PLUS 2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.
|
2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.
500 mg/day of psyllium husk fiber powder in a single #0 capsule.
|
|
Eksperimentel: Active, EM+Curc
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule PLUS 2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
|
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule PLUS 2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
VAS Muscle Soreness Rating
Tidsramme: 2 weeks
|
Changes in Visual Analog Scale (VAS) ratings of muscle soreness (rated from zero to 100 mm) from baseline following intense exercise.
The higher the rating, the more muscle soreness so negative changes in VAS would equate to improvement.
|
2 weeks
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Urinary CTX-II
Tidsramme: 2 weeks
|
Changes in urinary CTX-II biomarker from baseline following intense exercise.
|
2 weeks
|
|
Muscle Damage
Tidsramme: 2 weeks
|
Changes in markers of muscle enzyme efflux/damage (CK, LDH) from baseline following intense exercise.
|
2 weeks
|
|
Exercise Performance
Tidsramme: 2 weeks
|
Changes in exercise performance (strength, muscular endurance, peak aerobic capacity) from baseline following intense exercise.
|
2 weeks
|
|
Inflammation Biomarkers
Tidsramme: 2 weeks
|
Changes in markers of inflammation (TNFα, interleukin (IL) cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10) from baseline following intense exercise.
|
2 weeks
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Studieleder: Kevin J. Ruff, Ph.D., ESM Technologies, LLC
- Ledende efterforsker: Richard B. Kreider, Ph.D., Exercise & Sport Nutrition Lab, Texas A&M University
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. februar 2026
Primær færdiggørelse (Anslået)
15. oktober 2026
Studieafslutning (Anslået)
31. december 2026
Datoer for studieregistrering
Først indsendt
30. juli 2026
Først indsendt, der opfyldte QC-kriterier
10. august 2026
Først opslået (Faktiske)
14. august 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
14. august 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
10. august 2026
Sidst verificeret
1. august 2026
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Andre undersøgelses-id-numre
- STUDY2025-0899
Plan for individuelle deltagerdata (IPD)
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Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .