- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00005346
Mechanisms Underlying Abnormal Ambulatory BP Patterns
Study Overview
Status
Conditions
Detailed Description
BACKGROUND:
The blood pressure of a significant percentage of the hypertensive population, and the normotensive population at a high risk for the development of hypertension (Blacks and older individuals), is sodium (salt)-dependent. That is to say, increasing the intake of salt will increase blood pressure in these individuals; conversely, and more importantly, decreasing the intake of salt will reduce blood pressure.
DESIGN NARRATIVE:
The investigators believed that the mechanisms responsible for sodium-dependent blood pressure were only indirectly linked to race, sex, and age. Their research was consistent with the hypothesis that sodium-dependent blood pressure control resulted from decreased responsiveness of the renal and adrenal blood pressure regulatory systems. This produced abnormal daily blood pressure patterns, with reduced fluctuation resulting in extended periods of increased blood pressure. The increased cardiovascular load led to the early development of cardiovascular and renal disease, including hypertension. They tested this hypothesis by identifying 'high risk' and 'normal risk' subjects based on renal responses to sodium restriction. The subjects were equal numbers of healthy males and females, Blacks and whites, between the ages of 55-70 years. Using an innovative approach, they then examined the influence of risk status on 24-hour patterns of blood pressure, hormonal activity, and sodium handling. Finally, they determined the clinical significance of the profiles by examining changes in cardiac and renal status at a two-year follow-up.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Study Type
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Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
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How is the study designed?
Collaborators and Investigators
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More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 4215
- R01HL046177 (U.S. NIH Grant/Contract)
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