CP-609,754 in Treating Patients With Advanced Solid Tumors

Phase I Open-Label Study of the Safety, Toleration and Pharmacokinetics of CP-609,754, a Farnesyl Transferase Inhibitor, in Subjects With Advanced Malignant Tumors

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase I trial to study the effectiveness of CP-609,754 in treating patients who have advanced solid tumors.

Study Overview

• Status: Unknown
• Conditions: Unspecified Adult Solid Tumor, Protocol Specific
• Intervention / Treatment: Drug: CP-609,754

Detailed Description

OBJECTIVES: I. Determine the safety, tolerability, pharmacokinetics, and maximum tolerated dose of CP-609,754 in patients with advanced solid tumors. II. Determine the predictability, duration, intensity, onset, reversibility, and dose relationship of any observed toxicities in these patients when treated with this regimen. III. Determine any preliminary evidence of antitumor activity of this treatment as assessed by response rate and time to disease progression in this patient population.

OUTLINE: This is a dose escalation study. Patients receive oral CP-609,754 1-2 times daily. Treatment continues every 28 days for 12 courses in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of CP-609,754 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 6 patients experience dose limiting toxicities. Patients are followed at 4 weeks.

PROJECTED ACCRUAL: Approximately 44-56 patients will be accrued for this study within 12 months.

• Study Type: Interventional
• Phase: Phase 1

Contacts and Locations

Study Locations

• United States
  • Florida
    • Tampa, Florida, United States, 33612-9497
      • H. Lee Moffitt Cancer Center and Research Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

DISEASE CHARACTERISTICS: Histologically or cytologically confirmed advanced solid tumor No standard curative therapy exists OR Refractory OR Disease progression while on therapy Measurable disease No brain metastases or leptomeningeal disease

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: At least 12 weeks Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL AST and ALT no greater than 2.5 times upper limit of normal (ULN) (no greater than 5 times ULN if liver metastases) Renal: Creatinine no greater than 1.5 times ULN OR Creatinine clearance at least 60 mL/min Cardiovascular: No prior hemorrhagic or thrombotic cerebrovascular events including transient ischemic attacks No clinically significant or unstable cardiac disease No myocardial infarction within past 6 months No serious cardiac arrhythmia or conduction abnormality Pulmonary: No chronic obstructive pulmonary disease requiring hospitalization within past year Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective barrier contraception Female patients must use barrier contraception plus a second form of effective contraception for at least 3 months prior to and during study No other serious concurrent systemic disorders that would preclude study No uncontrolled diabetes mellitus, thyroid disease, or seizure disorder No active neurologic or psychiatric disease No clinically apparent uncontrolled infection (e.g., HIV, hepatitis B or C) No known sensitivity to imidazole containing drugs (e.g., clotrimazole, oxiconazole, sulconazole, econazole, etoconazole, metronidazole, or ketoconazole) No clinically significant gastrointestinal abnormalities requiring intravenous alimentation No malabsorption syndrome or active peptic ulcer No other lab abnormalities (i.e., electrolytes, uric acid, calcium, phosphorous, or glucose) that would preclude study No other malignancy in past 5 years except nonmelanomatous skin cancer or carcinoma in situ of the breast or cervix

PRIOR CONCURRENT THERAPY: Biologic therapy: At least 4 weeks since prior immunotherapy and recovered No prior bone marrow transplantation Chemotherapy: At least 4 weeks since prior chemotherapy (6 weeks for carboplatin, nitrosoureas, or mitomycin) and recovered Endocrine therapy: At least 1 week since prior hormonal therapy and recovered Concurrent hormone replacement therapy allowed No concurrent chronic steroid therapy Radiotherapy: At least 4 weeks since prior radiotherapy and recovered No prior radiotherapy to study lesions or to more than 30% of bone marrow containing areas Surgery: Not specified Other: At least 4 weeks since other prior investigational drugs No other concurrent investigational drugs Any regimens for other concurrent diseases or medical conditions must be stable for at least 4 weeks

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment

Collaborators and Investigators

• Sponsor: H. Lee Moffitt Cancer Center and Research Institute
• Collaborators: National Cancer Institute (NCI)
• Investigators: Study Chair: Daniel M. Sullivan, MD, H. Lee Moffitt Cancer Center and Research Institute

Study record dates

Study Major Dates

• Study Start: June 1, 2000

Study Registration Dates

• First Submitted: August 3, 2000
• First Submitted That Met QC Criteria: March 15, 2004
• First Posted (Estimate): March 16, 2004

Study Record Updates

• Last Update Posted (Estimate): December 19, 2013
• Last Update Submitted That Met QC Criteria: December 18, 2013
• Last Verified: December 1, 2001

More Information

Terms related to this study

• Keywords: unspecified adult solid tumor, protocol specific
• Additional Relevant MeSH Terms: Neoplasms
• Other Study ID Numbers: CDR0000068077; MCC-12222; PFIZER-A3321001; NCI-G00-1824