- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00057044
From Research to Practice - Lipid Management for Low HDL-Cholesterol
Study Overview
Status
Intervention / Treatment
Detailed Description
Background:
The overall purpose of this project is to improve the clinical outcomes of veterans with ischemic heart disease (IHD) through implementation of evidence-based lipid management, with a particular focus on veterans whose primary lipid abnormality is a low level of HDL-cholesterol (the �good� cholesterol).
Objectives:
The major objectives are 1. to determine whether a multifaceted intervention results in improved guideline-concordant lipid management for patients with low HDL-cholesterol; and 2. to test the relative effectiveness of three different reminder systems on physician prescribing behavior.
Methods:
The primary care clinic at each of the six VISN 13 facilities will serve as intervention sites. Within those sites we will randomize providers to one of three reminder systems. Control sites will consist of twelve other facilities matched to the intervention sites on the basis of facility characteristics. We will use a modified �pre-post� nested cohort design that allows us to evaluate the effect of the intervention controlling for secular trends. Target patients will be identified based on the following: 1. an IHD diagnosis within the past 5 years; 2. regular follow-up in a primary care clinic; 3. most recent LDL-cholesterol < 130 mg/dl and HDL-cholesterol < 40 mg/dl; 4. No lipid therapy within prior 6 months. The intervention will consist of: a. an on-site interactive educational workshop for providers; b. reminders (either patient-directed mailed reminders, computer-chart reminders at the time of visit, or automatic consults); c. opinion leader recruitment and �activation�. The primary outcome is proportion of target patients receiving guideline-concordant therapy. For objective 1, the outcome will be compared between intervention and control sites. For objective 2, the outcome will be compared between the three groups randomized to the different reminder systems. In addition, providers will be surveyed with a written questionnaire to determine their reaction to the educational workshop and the different reminder systems.
Status:
Intervention and data collection are completed. Data analysis is being undertaken, final report will soon follow.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Minnesota
-
Minneapolis, Minnesota, United States, 55417
- Minneapolis VA Health Care System, Minneapolis, MN
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
Subjects are primary care providers from participating VISN sites. Patients whose medical records are utilized are selected via an algorithm.
Exclusion Criteria:
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Arm 1
|
Collaborators and Investigators
Investigators
- Principal Investigator: Hanna E. Bloomfield, MD MPH, Minneapolis VA Health Care System, Minneapolis, MN
Study record dates
Study Major Dates
Study Start
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- TRX 01-083
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Coronary Heart Disease
-
Peking University Third HospitalCompletedCoronary Microvascular Dysfunction | Obstructive Coronary Heart DiseaseChina
-
Deutsches Herzzentrum MuenchenCompletedCoronary Heart DiseaseGermany
-
Centro de estudios en Cardiologia IntervencionistaCompletedCoronary Heart Disease | Coronary RestenosisArgentina
-
Second Affiliated Hospital, School of Medicine,...UnknownCHD - Coronary Heart DiseaseChina
-
Meir Medical CenterUnknown
-
Henan Institute of Cardiovascular EpidemiologyNot yet recruitingStable Coronary Heart Disease
-
Astana Medical UniversityCompletedCHD - Coronary Heart DiseaseKazakhstan
-
Second Affiliated Hospital, School of Medicine,...RenJi HospitalUnknown
-
Xiyuan Hospital of China Academy of Chinese Medical...UnknownStable Coronary Heart DiseaseChina
-
Charite University, Berlin, GermanyCompletedStable Coronary Heart DiseaseGermany
Clinical Trials on education and reminder
-
Yale UniversityNational Cancer Institute (NCI)CompletedColorectal CancerUnited States
-
Geisinger ClinicCompleted
-
Yale UniversityMedtronic - MITGCompleted
-
University of the PunjabSheikh Zayed Federal Postgraduate Medical InstituteCompletedDental CariesPakistan
-
Louisiana State University Health Sciences Center...Northwestern University; Loyola UniversityCompletedColorectal CancerUnited States
-
Barcey T. LevyAmerican Cancer Society, Inc.CompletedColorectal CancerUnited States
-
Memorial Sloan Kettering Cancer CenterHackensack Meridian HealthActive, not recruiting
-
ThinkWellUniversity of Oxford; Queen's University, Belfast; The BMJCompleted
-
University of California, Los AngelesLos Angeles County Department of Public HealthCompletedHuman Papilloma Virus InfectionUnited States