The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease

The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease by Two-dimensional Speckle-tracking Echocardiography

The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.

Study Overview

• Status: Completed
• Conditions: Coronary Microvascular Dysfunction; Obstructive Coronary Heart Disease
• Intervention / Treatment: Diagnostic test: Two dimensional speckle tracking imaging

Detailed Description

A total of 175 patients with chest pain, without wall motion abnormality and without significant coronary artery stenosis (<50%) assessed by coronary angiography or coronary computed tomography were enrolled from July 2011 to December 2017. Coronary flow reserve (CFR) of these patients were detected by transthoracic Doppler echocardiography. The patients were divided into coronary microvascular dysfunction group ( CFR≤2.5, n=67) and control group (CFR>2.5, n=108). At the same time, 67 age-matched patients with any major coronary arteries stenosis≥50% and without wall motion abnormality were involved into the obstructive coronary artery disease group. Parameters of global longitudinal strain (LS) and strain rate, subendocardial LS and subepicardial LS were quantified by 2D-STI, the differences of these parameters among three groups were analyzed，correlation analysis、univariate and multivariate analysis and receiver operating characteristic curve were used.

• Study Type: Observational
• Enrollment (Actual): 242

Contacts and Locations

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100191
      • Department of Cardiology, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 85 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

A total of 242 patients were enrolled, including 102 males (42.1%) and 140 females (57.9%). Their ages ranged from 44 to 81 years, with an average age of (62.6 + 8.3) years.

Description

Inclusion Criteria:

• age from 18-85 years

Exclusion Criteria:

• patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography
• patients with acute heart failure, chronic heart failure or LVEF values less than 50%
• patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation
• patients who did not store ultrasound images or whose ultrasound images were unclear
• patients who had incomplete clinical data

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
control group	Diagnostic test: Two dimensional speckle tracking imaging; lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging
coronary microvascular dysfunction group	Diagnostic test: Two dimensional speckle tracking imaging; lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging
obstructive coronary artery disease	Diagnostic test: Two dimensional speckle tracking imaging; lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
global longitudinal strain	global longitudinal strain of CMD group and obstructive CAD group	15/3/2018-30/12/2018

Collaborators and Investigators

• Sponsor: Peking University Third Hospital
• Investigators: Study Chair: Li Zhaoping, professor, Peking University Third Hospital

Study record dates

Study Major Dates

• Study Start (ACTUAL): March 15, 2018
• Primary Completion (ACTUAL): October 30, 2018
• Study Completion (ACTUAL): December 30, 2018

Study Registration Dates

• First Submitted: June 27, 2021
• First Submitted That Met QC Criteria: July 12, 2021
• First Posted (ACTUAL): July 13, 2021

Study Record Updates

• Last Update Posted (ACTUAL): July 13, 2021
• Last Update Submitted That Met QC Criteria: July 12, 2021
• Last Verified: July 1, 2021

More Information

Terms related to this study

• Keywords: strain; coronary microvascular dysfunction; two-dimensional speckle tracking imaging
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Heart Diseases; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
• Other Study ID Numbers: 048-01

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No