- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00101777
Ventilatory Physiology in Children at Risk for Anxiety
The importance of the proposed research project derives from a steady accumulation of research findings on the relationship between respiration and anxiety. The relationship between panic disorder and abnormalities in respiration has been recognized for more than 10 years. Increased sensitivity to CO2 exposure in panic disorder represents the most consistent finding supporting this relationship. The current proposal follows naturally from three sets of recent research findings in the area of panic disorder. First, our group has recently shown that children with anxiety disorders, like adults with panic disorder, exhibit increased sensitivity to CO2. Second, other researchers have shown that psychiatrically healthy relatives of patients with panic disorder also exhibit increased sensitvity to CO2. Finally, our group has also recently shown that children of adults with panic disorder exhibit high rates of anxiety disorders, particularly separation anxiety disorder, the childhood anxiety disorder which exhibits the highest degree of CO2 sensitivity. These three findings suggest that children of parents with panic disorder may exhibit a latent vulnerability to panic disorder, manifested as increased sensitivity to CO2.
A secondary feature of the proposed research project derives from a steady accumulation of research findings in basic science literature outlining the parts of the brain that mediate fear and anxiety in animals. It may be possible to use insights from research on the brain basis of fear in animals to develop methods for assessing the brain basis of fear in humans. Moreover, work in animals notes changes in brain systems that mediate fear and anxiety across development. If development. If developmentally sensitive methods could be used to study fear in children, it may also be possible to greatly enhance our understanding of the manner in which the relationship between brain function and fear changes as children age. If similarities could be demonstrated across animals and humans in these areas, new insights on potential treatments for anxiety could be more readily transferred from the laboratory to the clinic. A second goal of the current proposal is to refine two neuropsychological probes that are thought to assess functional aspects of brain systems implicated in fear and anxiety across various species, from rodents to humans.
Study Overview
Status
Conditions
Detailed Description
The importance of the proposed research project derives from a steady accumulation of research findings on the relationship between respiration and anxiety. The relationship between panic disorder and abnormalities in respiration has been recognized for more than 10 years. Increased sensitivity to CO2 exposure in panic disorder represents the most consistent finding supporting this relationship. The current proposal follows naturally from three sets of recent research findings in the area of panic disorder. First, our group has recently shown that children with anxiety disorders, like adults with panic disorder, exhibit increased sensitivity to CO2. Second, other researchers have shown that psychiatrically healthy relatives of patients with panic disorder also exhibit increased sensitvity to CO2. Finally, our group has also recently shown that children of adults with panic disorder exhibit high rates of anxiety disorders, particularly separation anxiety disorder, the childhood anxiety disorder which exhibits the highest degree of CO2 sensitivity. These three findings suggest that children of parents with panic disorder may exhibit a latent vulnerability to panic disorder, manifested as increased sensitivity to CO2.
A secondary feature of the proposed research project derives from a steady accumulation of research findings in basic science literature outlining the parts of the brain that mediate fear and anxiety in animals. It may be possible to use insights from research on the brain basis of fear in animals to develop methods for assessing the brain basis of fear in humans. Moreover, work in animals notes changes in brain systems that mediate fear and anxiety across development. If developmentally sensitive methods could be used to study fear in children, it may also be possible to greatly enhance our understanding of the manner in which the relationship between brain function and fear changes as children age. If similarities could be demonstrated across animals and humans in these areas, new insights on potential treatments for anxiety could be more readily transferred from the laboratory to the clinic. A second goal of the current proposal is to refine two neuropsychological probes that are thought to assess functional aspects of brain systems implicated in fear and anxiety across various species, from rodents to humans.
Study Type
Enrollment
Contacts and Locations
Study Locations
-
-
Maryland
-
Bethesda, Maryland, United States, 20892
- National Institute of Mental Health (NIMH)
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
INCLUSION CRITERIA (ALL OFFSPRING):
Ages greater than or equal to 9 years 0 months.
Parent able to give written informed consent.
Offspring ages 12 years 0 months to 17 years 11 months able to give written assent.
Offspring ages 9 years 0 months to 11 years 11 months able to give verbal assent.
Offspring ages 18 years 0 months.
Absence of medical condition that will interfere with CO(2) procedure.
INCLUSION CRITERIA (PARENTS):
Has met DSM-IV criteria for one or more of the following disorders:
Panic Disorder
Social Phobia
Major Depressive Disorder
OR No Disorder.
EXCLUSION CRITERIA (ALL OFFSPRING):
Clinically significant or unstable medical disorders; cardiovascular, hepatic, renal, gastrointestinal, pulmonary, metabolic, endocrine, hematological or other systemic disease.
History of mania, schizophrenia or other psychosis, or current serious suicidal ideation.
Females who are pregnant.
Children currently on medications that affect breathing.
IQ less than 70.
Study Plan
How is the study designed?
Collaborators and Investigators
Publications and helpful links
General Publications
- Papp LA, Klein DF, Martinez J, Schneier F, Cole R, Liebowitz MR, Hollander E, Fyer AJ, Jordan F, Gorman JM. Diagnostic and substance specificity of carbon-dioxide-induced panic. Am J Psychiatry. 1993 Feb;150(2):250-7. doi: 10.1176/ajp.150.2.250.
- Papp LA, Martinez JM, Klein DF, Coplan JD, Norman RG, Cole R, de Jesus MJ, Ross D, Goetz R, Gorman JM. Respiratory psychophysiology of panic disorder: three respiratory challenges in 98 subjects. Am J Psychiatry. 1997 Nov;154(11):1557-65. doi: 10.1176/ajp.154.11.1557.
- Perna G, Gabriele A, Caldirola D, Bellodi L. Hypersensitivity to inhalation of carbon dioxide and panic attacks. Psychiatry Res. 1995 Aug 28;57(3):267-73. doi: 10.1016/0165-1781(95)02723-a.
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 020093
- 02-M-0093
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Anxiety
-
AstraZenecaCompletedAnxiety Disorders | Anxiety | Anxiety Neuroses | Anxiety StatesUnited States
-
Prisma Health-UpstateCompletedAnxiety | Anxiety, Separation | Separation Anxiety | Anxiety Generalized
-
Ann & Robert H Lurie Children's Hospital of ChicagoUniversity of California, Los Angeles; University of CincinnatiRecruitingAnxiety, Separation | Anxiety, Social | Anxiety, GeneralizedUnited States
-
Yale UniversityNational Institute of Mental Health (NIMH)Active, not recruitingGeneralized Anxiety Disorder | Anxiety Disorder of Childhood | Separation Anxiety Disorder of Childhood | Social Anxiety Disorder of ChildhoodUnited States
-
Nazife Begüm KARANCompletedDental Anxiety | Sedative; Anxiety DisorderTurkey
-
Loyola UniversityCompletedAnxiety | Anxiety State | Procedural AnxietyUnited States
-
UCLH/UCL Joint Research OfficeMedical Research Council; Camden and Islington NHS Trust; Central and North West...RecruitingAnxiety Disorders | Anxiety | Anxiety Depression | CBT | Anxiety Disorders and Symptoms | Anxiety Generalized | Generalised Anxiety Disorder | Anxiety Disorder; Mixed With Depression (Mild) | Anxiety Disorder GeneralizedUnited Kingdom
-
Dr. Nazanin AlaviActive, not recruitingGeneralized Anxiety Disorder | AnxietyCanada
-
ProofPilotFisher WallaceActive, not recruitingGeneralized Anxiety Disorder | Anxiety | Generalized AnxietyUnited States
-
Loma Linda UniversityCompletedParental/Caregiver Anxiety | Child's AnxietyUnited States