Comparison of Pimecrolimus Cream 1% Twice-Daily to Once-Daily Dosing in the Management of Atopic Dermatitis in Pediatric Subjects

April 22, 2008 updated by: Novartis

This study is not being conducted in the United States.

To investigate the relative efficacy of pimecrolimus cream 1% applied twice daily (b.i.d.) versus once daily (o.d.) in preventing the progression to disease "relapse".

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
    • Basel
      • Novartis Pharma AG, Basel, Switzerland
        • This study is not being conducted in the United States

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

2 years to 17 years (Child)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion criteria - Screening/Run-In Period

  • age >= 2 years through age <=17 years of age
  • IGA score of 2, 3, or 4 (mild, moderate, or severe AD) affecting >5% TBSA
  • outpatients

Exclusion Criteria:Screening/Run-In period

  • subjects who applied topical therapy (e.g. tar, topical corticosteroids) within 2 weeks prior to Screening
  • subjects who received phototherapy (e.g. UVB, PUVA, Narrow Band) within 4 weeks of Screening
  • subjects who received any systemic immunosuppressant
  • subjects who received systemic steroids
  • females who are pregnant or breast-feeding, or planning to become pregnant during the study
  • subjects who are immunocompromised (e.g. lymphoma, AIDS, Wiskott-Aldrich syndrome) or have a history of malignancy (includes basal cell carcinoma, squamous cell carcinoma, melanoma)
  • subjects with open skin infections (bacterial, viral or fungal) if at the application site.
  • subjects will HSV (common cold sores) are allowed to participate in the study (if not at the application site).
  • subjects who have head lice or scabies
  • subjects who present with clinical conditions other than AD that may interfere with the evaluation (e.g., generalized erythroderma, acne, Netherton's Syndrome,psoriasis)
  • subjects that require systemic therapy for the treatment of atopic dermatitis
  • subjects with poor or no clinical response to tacrolimus ointment (Protopic®) or pimecrolimus cream 1%
  • subjects who used any experimental or investigational drug or therapy within 6 weeks prior to Screening
  • subjects who intend to use experimental or investigational drug therapy during the course of this study
  • subjects with known hypersensitivity to pimecrolimus 1% or related drugs (see Investigator's Brochure)
  • subjects who are non-compliant with general medical treatment, or are known to miss appointments, or don't intend to comply with the protocol for the duration of the study
  • drug abuse, mental dysfunction, or other factors limiting the subject's ability to cooperate fully with study-related procedures
  • subjects known to be unreliable or may be unable to complete the study
  • any condition or prior/present treatment that would render the subject ineligible for the study

Inclusion criteria - Double-blind Maintenance treatment period

- Achieve complete remission of active disease (no signs or symptoms of AD) without incidence of "relapse" by the end of 6-week Run-In period (may be earlier); or who achieve "disease improvement" (decrease in IGA score by 1 full point confirmed by the investigator) without incidence of relapse at the end of the 6-week Run-In period

Exclusion criteria - Double-blind Maintenance treatment period

  • subjects who experienced a "relapse" during the Run-In period
  • subjects who applied topical corticosteroids or any alternative or additional therapy for the treatment of AD during the Run-In period
  • subjects with active skin infections (bacterial, viral or fungal) except common cold sores (HSV) at the application site
  • subjects who failed to record study medication use (and non use) and dosing regimen during the Run-In period
  • subjects who failed to apply open label study drug twice daily until "disease remission" or end of the 6 week Run-In period
  • subjects who failed to record concomitant medications during the Run-In period
  • failure to return open-label study drug (used, partially used, and unused tubes) at the time double-blind study drug is dispensed. In order to avoid medication error, all open label study drug must be returned to the site before starting the Maintenance period

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 1
Pimecrolimus b.i.d.
Drug: Pimecrolimus
Pimecrolimus cream 1 % applied twice daily (b.i.d.)
Other Names:
  • Elidel b.i.d.
Drug: Pimecrolimus
Pimecrolimus cream 1 % applied once daily (o.d.) and placebo applied once daily (o.d.)
Other Names:
  • Elidel o.d.
Experimental: 2
Pimecrolimus o.d. and placebo o.d.
Drug: Pimecrolimus
Pimecrolimus cream 1 % applied twice daily (b.i.d.)
Other Names:
  • Elidel b.i.d.
Drug: Pimecrolimus
Pimecrolimus cream 1 % applied once daily (o.d.) and placebo applied once daily (o.d.)
Other Names:
  • Elidel o.d.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time to relapse of atopic dermatitis (defined as the exacerbation of atopic dermatitis to the level where a topical corticosteroid or alternative therapy is required).
Investigators Global Assessment (IGA) and pruritus (itch) assessment of atopic dermatitis at time of suspected relapse

Secondary Outcome Measures

Outcome Measure
Time to first recurrence of atopic dermatitis
Eczema Area and Severity Index (EASI) and IGA assessments at several time points.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Novartis

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2004

Study Completion (Actual)

September 1, 2005

Study Registration Dates

First Submitted

August 30, 2005

First Submitted That Met QC Criteria

August 30, 2005

First Posted (Estimate)

August 31, 2005

Study Record Updates

Last Update Posted (Estimate)

April 23, 2008

Last Update Submitted That Met QC Criteria

April 22, 2008

Last Verified

April 1, 2008

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CASM981C2314

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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