Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering

Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering


Lead sponsor: University Hospital Muenster

Source University Hospital Muenster
Brief Summary

The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.

Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.

Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.

The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.

Overall Status Unknown status
Start Date November 2004
Study Type Observational
Enrollment 20


Inclusion Criteria:

- Subjects with idiopathic stuttering (for the group of stutterers)

- Fluently speaking subjects (for the control group)

- Right handed

- Normal hearing

Exclusion Criteria:

- Neurological diseases

- Psychiatric diseases

- Medication with neurological effective drugs

- Implants with magnetic impact

Gender: Male

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: Accepts Healthy Volunteers

Overall Official
Overall Contact

Last name: Antoinette G Dinnesen, Prof. Dr.

Phone: +49(0)251 83

Phone ext: 56859

Email: [email protected]

facility status contact investigator
Institute for Biomagnetism and Biosignalanalysis | Münster, 48149, Germany Recruiting Christo Pantev, Prof. Dr. +49(0)251 83 56865 [email protected] Christo Pantev, Prof. Dr. Principal Investigator
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster | Münster, 48161, Germany Recruiting Antoinette G Dinnesen, Prof. Dr. +49(0)251 83 56859 [email protected] Antoinette G Dinnesen, Prof. Dr. Principal Investigator Arne Knief, Dr. Principal Investigator Michael Schneider Sub-Investigator
Location Countries


Verification Date

September 2006

Has Expanded Access No
Condition Browse
Study Design Info

Observational model: Defined Population, Natural History

Time perspective: Cross-Sectional, Prospective

Source: ClinicalTrials.gov