- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00504738
Lung Disease Collection (Qatar): Evaluation of the Lungs of Individuals With Lung Disease (Q-LD)
Evaluation of the Lungs of Individuals With Lung Disease With Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy (Qatar)
Study Overview
Status
Detailed Description
The lung diseases are disorders associated with functional and/or structural derangements to the alveolar structures, airways, pulmonary blood vessels, pleura and/or mediastinum. The purpose of this protocol is to obtain biologic materials from the blood and lungs from these patients in order to: (1) develop an understanding of the etiology and pathogenesis of these disorders; and (2) identify individuals who will be suitable candidates for other protocols such as those involving investigational new drugs. As such, this protocol is part of the "infrastructure" for all of our human lung-related studies such as genomic/gene expression studies of airway epithelium and alveolar macrophages in all individuals with chronic obstructive lung disease (COPD), asthma, bronchogenic carcinoma, and pulmonary fibrosis compared to normal non-smokers and smokers, and studies of mediators in bronchoalveolar lavage fluid.
This protocol, to be carried out at Weill Cornell Medical College - Qatar and Hamad Medical Corporation, Qatar, parallels a similar approved protocol IRB #0005004440, entitled, "Evaluation of the Lungs of Individuals with Lung Disease with Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy", ongoing at Weill Cornell Medical College - New York.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Doha, Qatar
- Hamad Medical Corporation
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
Inclusion/Exclusion criteria for Part A
- Must provide informed consent
- Males and females, age 18 years and older
Evidence of lung disease by at least one of the following:
- symptoms consistent with pulmonary disease;
- chest X-rays and/or chest CT consistent with lung disease;
- pulmonary function tests consistent with lung disease;
- lung biopsy consistent with lung disease;
- family history of lung disease;
- diseases of organs with known association with lung disease; and
- individuals suspected of having lung disease based on history and/or physical examination
- Undergoing fiberoptic bronchoscopy as dictated by their standard clinical care
Exclusion Criteria:
- Patient refuses consent.
Patients enrolled in Part A of the protocol will not undergo screening procedures/tests. These patients are undergoing a fiberoptic bronchoscopy as dictated by their standard clinical care and additional samples will be taken for research purposes.
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Prospective
Collaborators and Investigators
Investigators
- Principal Investigator: Ronald G. Crystal, MD, Weill Cornell Medical College, New York and Qatar
Study record dates
Study Major Dates
Study Start
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 0604008489
- HMC RC392/2006 (Other Identifier: Hamad Medical Corporation)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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