- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00511251
Analysis of Induced Sputum and Lung Biopsies by SEM: a Tool to Identify Source of Exposure of Workers to Hazardous Dust
Study Overview
Status
Conditions
Detailed Description
Abstract
Background: On the last few years there is a rise in the public awareness of the danger potential that lies in the exposure to hazardous dust in different professions. The examination of induced sputum has been used from the early eighties to research and diagnose inflammatory lung diseases. We assess here patients with lung disease and occupational history, in order to undergo work up to assess hazardous dust exposure.
Aim : to validate the qualitative analysis by Scanning Electron Microscope (SEM) of lung samples first in induced sputum in correlation to disease second by comparing hazardous particles in induced sputum to the analysis in lung tissue and finally by assessing if the particles present in transplanted patients correlated with occupational history.
Methods: 40 patients referred with occupational history were included. For 24 of them SEM analysis was done in induced sputum (IS) together with questionnaires and in 11 among them the SEM analysis was done both from lung tissue (TS) and IS. In addition 11 lung biopsies from patients with occupational history were scanned by SEM and compared to 10 biopsies from patients with no occupational history.
Study Type
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Occupational exposed workers
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Fireman Elizabeth, PhD, TASMC
Study record dates
Study Major Dates
Study Start
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- TASMC-07-LF-07226-CTIL
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Occupational Exposed Population
-
University of FloridaNational Aeronautics and Space Administration (NASA)CompletedMicrogravity Exposed Endothelial CellsUnited States
-
Johns Hopkins UniversityNational Institute on Drug Abuse (NIDA)Completed
-
University of Colorado, DenverNational Institute on Alcohol Abuse and Alcoholism (NIAAA)CompletedAlcohol Exposed PregnancyUnited States
-
Nationwide Children's HospitalCompletedExposed to AnesthesiaUnited States
-
University Hospital, Clermont-FerrandCompleted
-
University of Wisconsin, MadisonCompletedChildren Exposed to Adverse ExperiencesUnited States
-
Johns Hopkins UniversityCompleted
-
Assistance Publique - Hôpitaux de ParisCompleted
-
Institut National de la Santé Et de la Recherche...Commissariat A L'energie AtomiqueActive, not recruiting
-
University of BarcelonaUniversitat Oberta de CatalunyaCompletedGeneral PopulationSpain