- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00615706
Study to Evaluate the Impact of Obesity on Airway Inflammation and Mechanics in Asthmatics (ABI/BALA)
In the United States there has been a dramatic increase in the number of people who are obese and in the number of people who have asthma. Both are considered serious public health concerns. Several studies have shown that becoming obese or overweight can increase the risk of developing asthma or can make asthma symptoms more severe and difficult to control. How obesity affects asthma is not fully understood. This research study will examine whether obesity affects the amount of inflammation that is present in the lungs of people with asthma, and will also examine whether obesity leads to narrow and stiff airways.
Participation in this study involves 2 visits in order to complete questionnaires, various pulmonary function tests, as well as the collection of blood, urine, and exhaled breath condensate specimens.
This research study includes optional genetic and bronchoscopy substudies.
Study Overview
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
-
-
Georgia
-
Atlanta, Georgia, United States, 30308
- Emory University, Emory Crawford Long Hospital, Clinical Research Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Adults 18 to 70 years of age
- If asthmatic, currently taking a short acting beta agonist and an inhaled corticosteroid
- Never smoked or limited smoking history
Exclusion Criteria:
- Current upper respiratory illness (other than asthma)
- Illegal drug use within past month
- Consumption of more than 6 alcoholic drinks per week
- Active, pronounced rhinitis or sinusitis
- Pregnancy
- Currently taking oral steroids or steroid injection over the past month
- Asthma exacerbation over the past month
- Certain medical illnesses
Study Plan
How is the study designed?
Design Details
- Time Perspectives: Cross-Sectional
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
1
Asthmatics
|
no intervention
|
2
Healthy volunteers (without asthma)
|
no intervention
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 345-2004
- Emory IRB ID 345-2004
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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