Absorption Kinetics of Polyphenols in Angel's Plant (Angelica Keiskei)

April 24, 2017 updated by: Tufts University
The absorption kinetics of polyphenols in angel's plant (Angelica keiskei), which is a dark green leafy vegetable rich in antioxidant nutrients, will be determined in older adults in this pilot study.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

10

Phase

  • Early Phase 1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Massachusetts
      • Boston, Massachusetts, United States, 02111
        • Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

60 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy subjects (>60 yr, n=5)
  • subjects with metabolic syndrome (>60 yr, n=5)

  • Subjects who has

    • high fasting plasma glucose (>5.6 mmol/L),
    • central obesity (waist-hip ratio, >0.9 for men, >0.85 for women)
    • either high blood pressure (>130/85 mmHg) or high triacylglycerol (>1.7 mmol/L) will be selected to have metabolic syndrome.
  • normal hematological parameters, normal serum albumin, normal liver function, and normal kidney function
  • no history of smoking or alcoholism.

Exclusion Criteria:

  • consume >7 alcoholic drinks/wk
  • taking cholesterol medication or hormone replacement

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: NON_RANDOMIZED
  • Interventional Model: SINGLE_GROUP
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: 1
Healthy control, 5g dry power of angel's plant (Angelica keiskei)
Dietary supplement: angel's plant (Angelica keiskei)
Healthy control, one time dose of 5g dry power of Angelica keiskei
EXPERIMENTAL: 2
Metabolic syndrome, 5g dry powder of angel's plant (Angelica keiskei)
Dietary supplement: Angel's plant (Angelica keiskei)
Metaboic syndrome subjects, one time dose of 5g dry powder of angel's plant (Angelica keiskei)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Plasma quercetin
Time Frame: 0, 30, 60, 100, 180, 240, 300, 360, 420 & 480 min
0, 30, 60, 100, 180, 240, 300, 360, 420 & 480 min

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tufts University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2008

Primary Completion (ACTUAL)

March 1, 2009

Study Completion (ACTUAL)

December 1, 2010

Study Registration Dates

First Submitted

July 22, 2008

First Submitted That Met QC Criteria

July 23, 2008

First Posted (ESTIMATE)

July 24, 2008

Study Record Updates

Last Update Posted (ACTUAL)

April 25, 2017

Last Update Submitted That Met QC Criteria

April 24, 2017

Last Verified

April 1, 2017

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • HNRCA2580
  • BioGreen 20070301034009

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Oxidative Stress

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mozambique

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe