Pharmacokinetics of Carnosine

December 14, 2009 updated by: Tufts University
The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.

Study Overview

Study Type

Interventional

Enrollment (Actual)

4

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

    • Massachusetts
      • Boston, Massachusetts, United States, 02111
        • Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Female

Description

Inclusion Criteria:

  • Healthy adult
  • normal hematological parameters, normal serum albumin, normal liver function, normal kidney function

Exclusion Criteria:

  • History of smoking or alcoholism

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 1
Carnosine(450 mg)
one time dose of pure carnosine (450 mg)
Experimental: 2
Beef (150g)
one time dose, 150 g of beef
Experimental: 3
chicken (150g)
One time dose, 150g of chicken breast
Experimental: 4
Chicken broth (obtained from 150 g of chicken breast)
one time dose of chicken broth obtained from 150g of chicken breast

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Plasma histidine-dipeptide
Time Frame: 0, 30, 60, 100, 180, 240, & 300 min
0, 30, 60, 100, 180, 240, & 300 min

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2007

Primary Completion (Actual)

October 1, 2007

Study Completion (Actual)

July 1, 2008

Study Registration Dates

First Submitted

July 22, 2008

First Submitted That Met QC Criteria

July 23, 2008

First Posted (Estimate)

July 24, 2008

Study Record Updates

Last Update Posted (Estimate)

December 15, 2009

Last Update Submitted That Met QC Criteria

December 14, 2009

Last Verified

December 1, 2009

More Information

Terms related to this study

Other Study ID Numbers

  • TMC/TUHS IRB 7737

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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