Use of Electroconvulsive Therapy (ECT) in Chronic, Severe, Treatment Resistant Posttraumatic Stress Disorder

August 21, 2008 updated by: Government Medical College Srinagar

Efficacy of ECT in Chronic, Severe, Antidepressant- And CBT-Refractory Posttraumatic Stress Disorder: An Open, Prospective Study

Post Traumatic Stress Disorder is a chronic debilitating illness and few treatment options have demonstrated effectiveness. The study will look at the use of electroconvulsive therapy for the treatment of Post Traumatic Stress disorder in patients who have not responded to multiple antidepressants or cognitive behavioral therapy.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • India
    • Jammu & Kashmir
      • Srinagar, Jammu & Kashmir, India, 190003
        • Government Hospital for Psychiatric Disease

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Diagnosis of PTSD
  • Treatment resistance to 4 different antidepressants from 3 different classes
  • Treatment resistance to CBT
  • Severe PTSD

Exclusion Criteria:

  • Significant substance abuse
  • Pregnancy
  • History of Traumatic Brain Injury
  • Unstable comorbid medical illness
  • Organic brain syndrome

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Clinician-Administered Posttraumatic Stress Disorder Scale (CAPS) SCORE

Secondary Outcome Measures

Outcome Measure
Time Frame
Montgomery-Asberg Depression Rating Scale score
Time Frame: baseline, 48 hrs post 3rd, 6th ECT
baseline, 48 hrs post 3rd, 6th ECT

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Government Medical College Srinagar

Collaborators

Government Psychiatric Diseases Hospital, Srinagar

Investigators

  • Principal Investigator: Mushtaq Margoob, MD, Government Medical College Srinagar

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2005

Primary Completion (Actual)

December 1, 2005

Study Registration Dates

First Submitted

August 20, 2008

First Submitted That Met QC Criteria

August 21, 2008

First Posted (Estimate)

August 22, 2008

Study Record Updates

Last Update Posted (Estimate)

August 22, 2008

Last Update Submitted That Met QC Criteria

August 21, 2008

Last Verified

August 1, 2008

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • GMCPTSD_ECT2005

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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