Relationship of Staphylococcal Colonization to Infection

May 1, 2024 updated by: Veterans BioMedical Research Institute

Inpatients will be prospectively have nares screened and MRSA strains collected. All clinical MRSA strains of patients will also be prospectively collected. A sensitive strain discrimination test of spa typing will be used to determine if the strains are related. Hypotheses are

  1. Strain colonization durations vary and may be very short in days to weeks.
  2. Colonizing strains rarely infect 3) Both 1 and 2 may be affected by the patient's co-morbidity.

Study Overview

Status

Withdrawn

Conditions

Detailed Description

Patients of special interest:

  1. Skin and soft tissue infection
  2. Nursing home patients
  3. Vascular patients with leg lesions
  4. ICU patients
  5. Hemodialysis patients
  6. Outpatients without history of infections(controls) will have nares screened for MRSA and then monthly for 1 year.

All strains will be saved and spa typed. Analysis of the data will be performed to answer the questions and hypotheses and to answer is the screening effort and the isolation of patients for MRSA as is in current practice worthwhile and is there any scientific data to support this practice

Study Type

Observational

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

all patients admited

Description

Inclusion Criteria:

  • Admitted and one of the co-morbid groups
  • Ambulatory care patient with no infections

Exclusion Criteria:

  • All others

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
1
Hemodialysis
2
Intensive care
3
vascular patients with open wounds
4
nursing home
5
skin infections
6
control- ambulatory care clinic patients with no infections

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Percent of infection strains which were also colonizer earlier
Time Frame: 3 years
3 years

Secondary Outcome Measures

Outcome Measure
Time Frame
Duration of strain colonization among co-morbidity cohorts
Time Frame: 3 years
3 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Veterans BioMedical Research Institute

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2009

Primary Completion (Estimated)

June 1, 2011

Study Completion (Estimated)

June 1, 2012

Study Registration Dates

First Submitted

October 2, 2008

First Submitted That Met QC Criteria

October 2, 2008

First Posted (Estimated)

October 3, 2008

Study Record Updates

Last Update Posted (Actual)

May 3, 2024

Last Update Submitted That Met QC Criteria

May 1, 2024

Last Verified

March 1, 2021

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Eng-MRSA

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on MRSA Infection

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Armenia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe