Monitoring the Response of Port Wine Stain Birthmarks to Laser Therapy With Wide-field Functional Imaging Technologies

Monitoring the Response of Port Wine Stain Birthmarks to Laser Therapy With Wide-field

The researcher develop non-invasive imaging modalities for assessment of port wine stain during laser therapy treatment of Port Wine Stain. The imaging modalities will be used to guide immediate retreatment of regions of persistent perfusion during the procedure.

Study Overview

• Status: Completed
• Conditions: PORT WINE STAIN
• Intervention / Treatment: Device: Image-guided remove Port Wine Stain

Detailed Description

The researcher can use imaging system operates by projecting low-power near-infrared structured light patterns on to the tissue of interest in a non-contact, reflection geometry and then capturing the reflectance with a camera.The system can image the depth-resolved optical properties of in-vivo tissues, allowing rapid, non-invasive visualization of sub-surface structures of Port Wine Stain.

• Study Type: Observational
• Enrollment (Actual): 69

Contacts and Locations

Study Locations

• United States
  • California
    • Irvine, California, United States, 92612
      • Beckman Laser Institute Medical Clinic

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 1 day and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Study population will be selected from an outpatient population with Port Wine Stain birthmark at Beckman Laser Institute and Medical Clinic, University of California, Irvine. Patients with Port Wine Stain birthmark will be candidates for participation.

Description

Inclusion Criteria:

• All minors, birth to 18 years of age or older with Port Wine Stain birthmark
• Ability to understand and carry out subject instructions
• Sign photograph release form

Exclusion Criteria:

• Inability to understand and/or carry out instructions
• Pregnant women
• Do not sign photograph release form

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Only
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Image-guided remove Port Wine Stain; Image-guided surgery remove Port Wine Stain	Device: Image-guided remove Port Wine Stain; Image-guided surgery remove Port Wine Stain

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Image-guided surgery remove Port Wine Stain	Image-guided surgery remove Port Wine Stain	24 hours

Collaborators and Investigators

• Sponsor: University of California, Irvine
• Collaborators: Beckman Laser Institute University of California Irvine
• Investigators: Principal Investigator: Bernard Choi, PhD, Beckman Laser Institute University of California Irvine

Study record dates

Study Major Dates

• Study Start: April 1, 2010
• Primary Completion (Actual): April 1, 2018
• Study Completion (Actual): April 1, 2018

Study Registration Dates

• First Submitted: August 3, 2010
• First Submitted That Met QC Criteria: April 8, 2011
• First Posted (Estimate): April 12, 2011

Study Record Updates

• Last Update Posted (Actual): November 1, 2022
• Last Update Submitted That Met QC Criteria: October 28, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Keywords: birthmark
• Additional Relevant MeSH Terms: Skin Diseases; Neoplasms by Histologic Type; Neoplasms; Congenital Abnormalities; Skin Abnormalities; Hemangioma; Neoplasms, Vascular Tissue; Hemangioma, Capillary; Port-Wine Stain
• Other Study ID Numbers: 20107376