Pathogenic Mechanisms of Port Wine Stain and Repository of Port Wine Stain Biopsy Samples

October 28, 2022 updated by: Beckman Laser Institute and Medical Center, University of California, Irvine
The purpose of this study is to investigate the pathogenic mechanisms of Port Wine Stain, collect biopsy samples and blood samples to characterize exosomes and metabolites from Port Wine Stain.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The researcher can detect the defects in nervous system innervation to cutaneous blood vessels contribute to the pathogenesis of Port Wine Stain . Unveiling the pathogenic mechanisms of PWS is crucial to the design of new therapeutic strategies and can use the results to improve current PWS therapeutic outcomes.

Study Type

Interventional

Enrollment (Actual)

19

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Irvine, California, United States, 92612
        • Beckman Laser Institute

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

1 day and older (ADULT, OLDER_ADULT, CHILD)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Male or female of all ages.
  • Not pregnant.
  • Has diagnosis of port wine stain on the arms, legs, chest, bac.
  • Ability to understand and carry out subject instructions.
  • Subject willing to have skin biopsies on port wine stain and normal skin areas.

Exclusion Criteria:

  • Pregnant women.
  • Port Wine Stain on the face.
  • History of skin cancer.
  • Current participation in an investigational drug evaluation
  • Concurrent use of known photosensitizing drugs.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: NA
  • Interventional Model: SINGLE_GROUP
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
OTHER: Port Wine Stain Birthmark
Biopsy sample from Port Wine Stain Birthmark
Other: Biopsy sample from Port Wine Stain Birthmark
Biopsy sample from Port Wine Stain Birthmark

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Characterization of Port Wine Stain Birthmark tissue sample
Time Frame: up to 4 weeks
up to 4 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of California, Irvine

Collaborators

Beckman Laser Institute University of California Irvine

Investigators

  • Study Director: John s Nelson, MD, Beckman Laser Institute, UCI
  • Principal Investigator: Winbin Tan, PhD, Beckman Laser Institute

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

April 23, 2013

Primary Completion (ACTUAL)

January 11, 2019

Study Completion (ACTUAL)

January 11, 2019

Study Registration Dates

First Submitted

November 6, 2013

First Submitted That Met QC Criteria

January 29, 2014

First Posted (ESTIMATE)

January 31, 2014

Study Record Updates

Last Update Posted (ACTUAL)

November 1, 2022

Last Update Submitted That Met QC Criteria

October 28, 2022

Last Verified

October 1, 2022

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 20139396

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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