The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

The Correlation Between BNP and Global End Diastolic Volume

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Study Overview

• Status: Completed
• Conditions: Critically Ill

• Study Type: Observational
• Enrollment (Actual): 46

Contacts and Locations

Study Locations

• China
  • Zhejiang
    • Jinhua, Zhejiang, China, 321000
      • Jinhua Central Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

critically ill patients who required hemodynamic monitoring using PiCCO

Description

Inclusion Criteria:

• critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion Criteria:

• patients with renal dysfunction
• those older than 80 years
• pregnant women

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
consecutive patients; there is only one group in our study

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
global end diastolic volume	this is measured by transpulmonary thermodilution technique	within 12 h after measurement of BNP

Collaborators and Investigators

• Sponsor: Jinhua Central Hospital
• Investigators: Study Chair: Zhongheng Zhang, MD, Jinhua Central Hospital

Study record dates

Study Major Dates

• Study Start: June 1, 2010
• Primary Completion (Actual): October 1, 2011
• Study Completion (Actual): October 1, 2011

Study Registration Dates

• First Submitted: April 27, 2011
• First Submitted That Met QC Criteria: April 28, 2011
• First Posted (Estimate): April 29, 2011

Study Record Updates

• Last Update Posted (Estimate): April 4, 2013
• Last Update Submitted That Met QC Criteria: April 1, 2013
• Last Verified: September 1, 2012

More Information

Terms related to this study

• Keywords: B-type natriuretic peptide; global end diastolic volume
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Critical Illness
• Other Study ID Numbers: zh_zhang1984