- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01466426
The Role of FDG-PET/CT Imaging in the Management of Patients With Thromboembolic Disorders (The PETVET Study) (PETVET)
The Role of FDG-PET/CT Imaging in the Management of Patients With Thromboembolic Disorders
Study Overview
Status
Conditions
Detailed Description
Acute DVT and PE are common and serious conditions. Highly effective treatment (most often anticoagulant agents) is available for acute VTE, but it is associated with potentially dangerous side effects. In addition, DVT and PE are just two manifestations of VTE, which can occur everywhere in the human organism. An underlying disease (i.e. cancer) is often a key factor in developing VTE.
Commonly used diagnostic imaging techniques in DVT and PE have a fair diagnostic accuracy, but do not address other important aspects of the disease. In contrast to this, FDG-PET/CT has the potential to contribute in VTE diagnosis by
- Differentiate between acute and chronic VTE
- Screening of the entire body for VTE (e.g. the pelvis where normal imaging techniques fail)
- Early diagnosis of underlying disease (e.g. cancer, with the possibility of early treatment)
This is a pilot study with the above mentioned objectives, and is part of a larger study addressing other aspects of FDG-PET/CT in VTE.
The investigators believe that their hypothesis that FDG-PET/CT imaging may introduce a new approach for detecting thrombi anywhere in the body, particularly in the venous system including the pelvis and the calves, will add a new dimension in treating patients with suspected PE. This technology will only detect acute thrombi and not chronic thrombi that no longer have activity, which will obviate unnecessary treatment in this population.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Odense, Denmark, dk-5000
- Dept. of Acute Medicine, Odense University Hospital
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Odense, Denmark, dk-5000
- Dept. of Nuclear Medicine, Odense University Hospital
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Odense, Denmark, dk-5000
- Dept. of Respiratory Medicine, Odense University Hospital,
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Positive or negative diagnosis of VTE (DVT/PE)
- Age ≥ 50 years
- Informed consent obtained
- Symptoms < 1 week
Exclusion Criteria:
- Pregnant or lactating women
- Foreign language patients with a need for an interpreter
- Previous DVT or PE
- Known malignancy
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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DVT confirmed
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DVT ruled out
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PE confirmed
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PE ruled out
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Proof-of-concept
Time Frame: During diagnostic workup
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Simple assessment of scans - positive or negative in the relevant patient categories
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During diagnostic workup
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Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Soeren Hess, MD, Odense University Hospital
- Study Chair: Poul Henning Madsen, MD, Odense University Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NMA projekt K 59 PETVET
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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