- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01708083
Polymorphids an mRNA Expression in Obese Genes
Polymorphids and mRNA Expression in Genes, Significant for Developing Obesity and Typ II Diabetes in Different Types/Localisations of Fat Tissue
Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).
Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .
Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue
Study Overview
Status
Conditions
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Stockholm, Sweden, 171 76
- Karolinska Institutet, CMM
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Stockholm County Council
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Stockholm, Stockholm County Council, Sweden, 116 91
- Ersta Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- age 18 years or older
- laparoscopic surgery (Gastric by-pass, cholecystectomy, antireflux surgery)
- Normal weight without type 2 diabetes BMI 18-25
- Obese without type 2 diabetes BMI>35
- Obese with type 2 diabetes BMI>35
Exclusion Criteria:
- under 18 years
- open surgery
- pregnancy
- BMI >27-<35
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Type 2 Diabetes and BMI>35
Patients with type 2 diabetes and body mass index 35 or more.
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BMI>35
Patients undergoing surgery, gastric bypass or cholecystectomy, without diabetes type 2 and body mass index 35 or more
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BMI 18-27
Patients undergoing surgery, cholecystectomy or reflux, without type 2 diabetes and body mass index between 18-27
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity
Time Frame: approximatly 30 minutes after start of operation
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fat biopsy taken from abdomen, omenta and thigh at surgery
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approximatly 30 minutes after start of operation
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Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2
Time Frame: approximatly 30 minutes after start of operation
|
fat biopsy; abdomen, omenta and thigh taken at surgery
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approximatly 30 minutes after start of operation
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Anders Thorell, Ass. prof., Karolinska Institutet
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 2009/1629-31/3
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