- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01742520
Neurodevelopmental Outcomes of Preterm Infants Treated for Pain Management With Repeated Doses of Sucrose 24%
Its an Interventional Study That Will Evaluate the Effect of Different Doses of Sucrose 24% on Neurodevelopmental Outcome of Preterm Infants
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
preterm infants born at 27-33 weeks gestational age at Sheba Medical Center will be recruited for this study. Prior to invasive procedure infants will be treated with pacifier and swaddling as recommended by the American Academy of Pediatrics and Canadian Pediatric Society.
Group 1.Will be treated with Sucrose 24% 0.1-0.5ml on the anterior pat of the tongue 1-3 min prior to invasive procedure.
Group 2. Similar to group 1 but breast milk or formula will replace Sucrose.
Number of invasive procedures/day will be documented
General Movements by Prechtel will be used for developmental assessment at 2,4,6 weeks after birth and at 14-16 weeks corrected age
Griffiths developmental scales (GMDS) will be used at 40 weeks, 14-16 weeks corrected age, and 3-6 month corrected age
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Iris Morag, MD
- Phone Number: +972526479996
- Email: irismorag@gmail.com
Study Contact Backup
- Name: Tzipi Strauss, MD
- Phone Number: +97235302215
- Email: t.tzipi@gmail.com
Study Locations
-
-
-
Ramat Gan, Israel
- Recruiting
- Sheba Medical Center
-
Contact:
- Iris Morag, MD
- Phone Number: +9725307170
- Email: irismorag@gmail.com
-
Contact:
- Tzipora Strauss, MD
- Phone Number: +9725302227
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- preterm infants born at SMC
Exclusion Criteria:
- need for intubation
- surgery
- need for sedation
- abnormal head ultrasound
- genetic abnormalities
- necrotizing enterocolitis
- other painful conditions other than routine blood exams
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Formula or Breast Milk
Breast milk or formula prior to every painful procedure.
|
1-3 minutes prior to every painful procedure, breast milk or formula 0.5-1 ml will be given on the anterior part of the tongue
Other Names:
|
Active Comparator: Multiple doses of sucrose
Infants in this group will be treated with Sucrose 24% 0.5-1ml on the anterior pat of the tongue 1-3min prior to every invasive procedure
|
unlimited number of doses par day- current status in our NICU
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
neurodevelopmental outcomes
Time Frame: at 6 month corrected age
|
Griffith mental developmental scaled (gross and fine motor, language, performance, social) and General movements by Prechtel
|
at 6 month corrected age
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
neurodevelopment
Time Frame: at 15 weeks corrected age
|
Griffith mental developmental scaled (gross and fine motor, language, performance, social) and General movements by Prechtel
|
at 15 weeks corrected age
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- SHEBA-12-9389-IM-CTIL
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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