Lung Sonography in Patients With Acute Respiratory Distress Syndrome in Intensive Care Unit

The purpose of this study is to evaluate the role of lung sonography during different PEEP settings in ICU patients with ARDS.

Study Overview

• Status: Completed
• Conditions: ARDS

Detailed Description

Acute respiratory distress syndrome (ARDS) is a clinical syndrome that often occurs in critically ill patients.

Patients with ARDS invariably require mechanical ventilation to improve oxygen transport. An improvement in oxygenation can be obtained by an increase in positive end-expiratory pressure (PEEP).

In critically ill patients with ARDS, lung imaging is been held by the use of chest radiography and the "gold standard" technique, Computed Tomography (CT).

We designed an observational study in which we included patients under mechanical ventilation admitted in our ICU. In all patients PEEP changes were applied and lung sonography was performed.

• Study Type: Observational
• Enrollment (Actual): 10

Contacts and Locations

Study Locations

• Greece
  • Attiki
    • Athens, Attiki, Greece, 10676
      • First Critical Care Unit, Evaggelismos Hospital, School of Medicine, University of Athens

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 90 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

ICU population

Description

Inclusion Criteria:

• Critically ill patients with ARDS admitted in ICU of Evangelismos Hospital
• length of stay > 48 hours

Exclusion Criteria:

• age < 18 years
• emphysema fractures or skin lesions that do not allow the implementation of lung sonography
• BMI > 35 kg/m2
• length of stay < 48 hours

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Non aerated lung area changes	20 min after PEEP trial

Secondary Outcome Measures

Outcome Measure	Time Frame
Arterial oxygen and carbon dioxide partial pressure	20 min after PEEP trial

Collaborators and Investigators

• Sponsor: University of Athens
• Investigators: Study Chair: Serafim Nanas, MD, University of Athens

Publications and helpful links

General Publications

• Stefanidis K, Dimopoulos S, Tripodaki ES, Vitzilaios K, Politis P, Piperopoulos P, Nanas S. Lung sonography and recruitment in patients with early acute respiratory distress syndrome: a pilot study. Crit Care. 2011 Aug 4;15(4):R185. doi: 10.1186/cc10338.

Study record dates

Study Major Dates

• Study Start: September 1, 2009
• Primary Completion (ACTUAL): December 1, 2011
• Study Completion (ACTUAL): December 1, 2011

Study Registration Dates

• First Submitted: June 17, 2013
• First Submitted That Met QC Criteria: June 18, 2013
• First Posted (ESTIMATE): June 19, 2013

Study Record Updates

• Last Update Posted (ESTIMATE): June 19, 2013
• Last Update Submitted That Met QC Criteria: June 18, 2013
• Last Verified: June 1, 2013

More Information

Terms related to this study

• Keywords: ICU; PEEP; Sonography
• Other Study ID Numbers: UOA-US-2010