LDH as a Biochemical Biomarker to Predict Organ Failure in the Emergency Department Setting

The purpose of this study is evaluate if K3, a novel biomarker, sampled at arrival to the emergency department can be used to predict the development of organ failure measured as SOFA score. K3 consists of lactate dehydrogenase, albumin and magnesium combined.

Study Overview

• Status: Completed
• Conditions: Multiple Organ Failure

• Study Type: Observational
• Enrollment (Actual): 1250

Contacts and Locations

Study Locations

• Sweden
  • Karlstad, Sweden
    • Karlstad Central Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All adult patients admitted to emergency department during study period.

Description

Inclusion Criteria:

• Age ≥18 years
• Admitted to emergency department, Karlstad Central Hospital, Sweden

Exclusion Criteria:

• Not in need of venous blood sample

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Adults admitted to ER; All adult patients admitted to emergency department during the study period.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Development of multiple organ failure	Measured as SOFA score.	30 days or complete ICU stay

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cardiac function	Is it possible to predict cardiac function with the novel biomarker K3, which consists of lactate dehydrogenase, albumin, and magnesium combined?	30 days or complete ICU stay
All cause mortality		30 days after admission to emergency department

Collaborators and Investigators

• Sponsor: Karolinska Institutet
• Investigators: Principal Investigator: Mathias Karlsson, MD, PhD, Karolinska; Study Director: Jan Wernerman, MD, Prof, Karolinska; Study Director: Lars Wiklund, MD, Prof, Uppsala University

Study record dates

Study Major Dates

• Study Start: September 1, 2013
• Primary Completion (Actual): April 1, 2014

Study Registration Dates

• First Submitted: August 30, 2013
• First Submitted That Met QC Criteria: September 4, 2013
• First Posted (Estimate): September 9, 2013

Study Record Updates

• Last Update Posted (Estimate): September 7, 2016
• Last Update Submitted That Met QC Criteria: September 3, 2016
• Last Verified: September 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Shock; Emergencies; Multiple Organ Failure
• Other Study ID Numbers: K3-akuten