Screening Cardiovascular Patients for Aortic aNeurysms (SCAN) (SCAN)

The aim of the cohort study SCAN (Screening Cardiovascular patients for Aortic aNeurysms) is to establish a screening programm for patients with a high risk for an AAA. Aortic aneurysms in these patients should be identified at an early stage and thereby AAA-associated mortality be decreased.

Study Overview

• Status: Unknown
• Conditions: Abdominal Aortic Aneurysm; AAA

Detailed Description

A recently published meta-analysis showed a higher prevalence of aortic aneurysm (AAA) in men requiring treatment of coronary heart disaese compared to standard population. In women, however, the prevalence was not increased. Thus, the SCAN project addresses male patients who underwent coronary artery intervention in order to screen them for the presence of an AAA using duplex sonography.

The SCAN project involves the following elements:

1. Informing the patient with cardiovascular risk factors about the clinical picture of AAA
2. An ultrasound scan of the abdominal aorta in patients with an increased risk for AAA
3. Acquisition of patient data followed by a correlation analysis for the parameters presence of AAA and cardiovascular diseases

The cohort study is part of the SCAN project which is also conducted in an similar way by Catharina Ziekenhuis Eindhoven ClinicalTrials.gov Identifier:NCT01643317.

• Study Type: Observational
• Enrollment (Anticipated): 1000

Contacts and Locations

Study Locations

• Germany
  • Bayern
    • Munich, Bayern, Germany, 81675
      • Recruiting
      • Klinikum rechts der Isar, Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie
      • Contact: Hans-Henning Eckstein, Univ.-Prof.Dr.med.; Phone Number: 2167 0049894140; Email: gefaesschirurgie@lrz.tum.de
      • Contact: Benedikt Reutersberg, Dr. med.; Phone Number: 2166 0049894140; Email: gefaesschirurgie@lrz.tum.de
      • Principal Investigator: Hans-Henning Eckstein, Prof.Dr.med.
      • Sub-Investigator: Benedikt Reutersberg
    • München, Bayern, Germany, 81675
      • Recruiting
      • I. Medizinischen Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München
      • Contact: Karl-Ludwig Laugwitz, Univ.-Prof.Dr.med.; Phone Number: 2350 +49 (0) 89 4140; Email: sekretariat-laugwitz@tum.de
      • Principal Investigator: Karl-Ludwig Laugwitz, Univ.-Prof.Dr.med.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

• Sampling Method: Non-Probability Sample

Study Population

Men with coronary artery intervention (PTCA/stenting) and at least 1 risk factor for AAA (hypertension, hyperlipidaemia, hyperuricemia, nicotine abuse,positive family history.

Description

Inclusion Criteria:

• men with coronary artery intervention (PTCA/stenting)
• at least 1 risk factor for AAA (hypertension, hyperlipidaemia, hyperuricemia, nicotine abuse,positive family history)

Exclusion Criteria:

• life expectancy less than 1 year
• inability to follow the instructions of the investigator (dementia, lack of time, insufficient understanding of the language)
• insufficient compliance

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Prevalence of AAA	Ultrasound screen for the presence of an AAA	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Prevalence of AAA in the cohort requiring treatment	Measuring the AAA diameter	1 year
Correlation of risk factors for AAA with risk factors for coronary artery disease	Therefore the cardiovascular risk factors ( diabetes, hypertension, hyperlipidaemia, hyperuricemia, nicotine abuse, positive family history, obesity) will be requested.	1 year
Distribution of risk factors	Distribution of cardiovascular risk factors (diabetes, hypertension, hyperlipidaemia, hyperuricemia, nicotine abuse, positive family history, obesity) between patients with an without an AAA	1 year
Correlation of the number of treated vessels and AAA		1 year

Collaborators and Investigators

• Sponsor: Technical University of Munich
• Collaborators: I. Medizinischen Klinik und Poliklinik, Technical University of Munich
• Investigators: Principal Investigator: Hans-Henning Eckstein, Univ.-Prof.Dr.med., Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar der Technische Universität München; Principal Investigator: Karl-Ludwig Laugwitz, Univ.-Prof.Dr.med., I. Medizinischen Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München

Publications and helpful links

Helpful Links

• Homepage of the Department for Vascular and Endovascular Surgery

Study record dates

Study Major Dates

• Study Start: March 1, 2014
• Primary Completion (Anticipated): December 1, 2017
• Study Completion (Anticipated): April 1, 2018

Study Registration Dates

• First Submitted: June 12, 2014
• First Submitted That Met QC Criteria: June 30, 2014
• First Posted (Estimate): July 2, 2014

Study Record Updates

• Last Update Posted (Estimate): January 6, 2017
• Last Update Submitted That Met QC Criteria: January 5, 2017
• Last Verified: January 1, 2017

More Information

Terms related to this study

• Keywords: Screening; AAA; Abdominal aortic aneurysm
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Aortic Diseases; Aneurysm; Aortic Aneurysm; Aortic Aneurysm, Abdominal
• Other Study ID Numbers: GES_SCAN