Effect of Opicapone at Steady State on Warfarin Pharmacokinetics

Effect of Opicapone at Steady State on Warfarin Pharmacokinetics in Healthy Volunteers

Single-centre, open-label, fixed-sequence design consisting of 2 periods separated by a washout period of at least 14 days.

Study Overview

• Status: Completed
• Conditions: Parkinson's Disease
• Intervention / Treatment: Drug: Warfarin; Drug: BIA 9-1067

Detailed Description

Single-centre, open-label, fixed-sequence design consisting of 2 periods separated by a washout period of at least 14 days. In Period 1, a single dose of 25 mg warfarin was administered alone. In Period 2, subjects received 475 mg OPC, on Day 1 and D2 followed by 50 mg OPC once daily for 5 days (D3 to D7). On D8, 50 mg OPC was administered with a single dose of 25 mg warfarin.

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Phase 1

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• A signed and dated informed consent form before any study-specific screening procedure was performed,
• Male or female subjects aged 18 to 45 years, inclusive,
• Body mass index (BMI) between 18 and 30 kg/m2,
• Healthy as determined by pre-study medical history, physical examination, vital signs, complete neurological examination and 12-lead electrocardiogram (ECG),
• Negative tests for hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (HCV) antibodies and anti-human immunodeficiency virus (HIV) antibodies at screening,
• Clinical laboratory test results clinically acceptable at screening and at admission to each inpatient period,
• Negative screen for alcohol and drugs of abuse at screening and at admission to each inpatient period,
• Non-smokers or ex-smokers for at least 3 months,
• Able to participate, and willing to give written informed consent and comply with the study restrictions,
• Able to swallow a high number of capsules within a short time frame,

If female:

• Was not of childbearing potential by reason of surgery or, if of childbearing potential, used an effective non-hormonal method of contraception (intrauterine device or intrauterine system; condom or occlusive cap [diaphragm or cervical or vault caps] with spermicidal foam or gel or film or cream or suppository; true abstinence; or vasectomized male partner, provided that he was the sole partner of that subject) for the entire duration of the study,
• Negative serum pregnancy test at screening and a negative urine pregnancy test at admission to each inpatient period.

Exclusion Criteria:

• Any clinically relevant history or presence of respiratory, gastrointestinal, renal, hepatic, haematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, endocrine, connective tissue diseases or disorders, or had a clinically relevant surgical history,
• Any personal or family history of haemostatic disorder,
• Any personal or family history of bleeding complications after surgery or tooth extraction, nose or gingival bleeding, or haemorrhagic diathesis,
• Any clinically relevant findings in the laboratory tests, particularly any abnormality in the coagulation tests or the liver function tests,
• History of relevant atopy or drug hypersensitivity,
• History of alcoholism and/or drug abuse,
• Current consumption of more than 14 units of alcohol per week [1 unit of alcohol = 280 mL beer (3-4°) = 100 mL wine (10-12°) = 30 mL spirits (40°)],
• Any significant infection or known inflammatory process on screening or admission to each treatment period; any acute gastrointestinal symptoms (e.g., nausea, vomiting, diarrhoea, heartburn) at the time of screening or admission to each treatment period,
• Use of medicines within 2 weeks of admission to first period that could affect the subject's safety or other study assessments, in the investigator's opinion, or intake of any of the prohibited medications (i.e., CYP2C9 inhibitor taken within 1 week prior to start of administration of study drug, and CYP2C9 inducer taken within 4 weeks prior to dosing),
• Previous use of opicapone,
• Use of any investigational drug or participation in any clinical trial within 3 months prior to screening; participation in more than 2 clinical trials within the 12 months prior to screening,
• Blood donation or receipt of any blood transfusion or any blood products within the 3 months prior to screening,
• Vegetarian, vegan or had medical dietary restrictions,
• Not able to communicate reliably with the investigator,
• Unlikely to co-operate with the requirements of the study,
• Unwilling or unable to give written informed consent,
• CYP2C9 poor metaboliser, as assessed by genotyping,

If female:

• Pregnant or breast-feeding.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: BIA 9-1067 / Warfarin; BIA 9-1067 capsules of 25 mg or 50 mg Warfarin capsules of 5 mg	Drug: Warfarin; Other Names: Uniwarfin; Drug: BIA 9-1067; Other Names: OPC, Opicapone

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
R- and S-warfarin plasma concentration	pre-dose and 0.5, 1, 2, 3, 4, 6, 8, 12, 16, 24, 36, 48, 60, 72, 96, 120 and 144 h post-warfarin

Secondary Outcome Measures

Outcome Measure	Time Frame
Opicapone plasma concentration	D1 pre-dose, and on D8 at the following time points: pre-dose, 0.5, 2, 4, 6, and 8 h post-opicapone dose
BIA 9-1103 (sulphate metabolite) plasma concentration	D1 pre-dose and from D5 to D7 pre-dose, and on D8 at the following time points: pre-dose, 0.5, 2, 4, 6, 8, 24, 48, 72 and 144 h post-opicapone dose.

Collaborators and Investigators

• Sponsor: Bial - Portela C S.A.

Study record dates

Study Major Dates

• Study Start: March 1, 2014
• Primary Completion (Actual): May 1, 2014
• Study Completion (Actual): May 1, 2014

Study Registration Dates

• First Submitted: November 28, 2014
• First Submitted That Met QC Criteria: November 28, 2014
• First Posted (Estimate): December 2, 2014

Study Record Updates

• Last Update Posted (Estimate): December 2, 2014
• Last Update Submitted That Met QC Criteria: November 28, 2014
• Last Verified: November 1, 2014

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Parkinson Disease; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Anticoagulants; Antiparkinson Agents; Anti-Dyskinesia Agents; Catechol O-Methyltransferase Inhibitors; Warfarin; Opicapone
• Other Study ID Numbers: BIA-91067-127