Protein Requirements In Active Female Populations

Evaluation of Protein Requirements in Active, Young Adult Females

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.

The purpose of this study is to measure the protein requirement in active, young adult females using the IAAO technique in the presence of a variable intensity exercise stimulus.

Study Overview

• Status: Completed
• Conditions: Healthy; Increased Metabolic Requirement
• Intervention / Treatment: Dietary supplement: Amino acid intake

• Study Type: Interventional
• Enrollment (Actual): 6
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Healthy, active, young adult females who regularly participate in moderate-vigorous activity 5x per week, for a minimum of 1 hour
• A minimum score of 10 on the Beep Test (a measure of aerobic fitness)

Exclusion Criteria:

• Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
• Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
• Regular tobacco use
• Illicit drug use

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Active, Young Adult Famale; Participants will complete a bout of exercise and then consume a randomly assigned amino acid intake prior to measuring whole body 13CO2 excretion and phenylalanine oxidation.	Dietary supplement: Amino acid intake; Amino acid intakes will be varied at 0.2-2.6 g/kg/day

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
13CO2 (carbon dioxide) excretion (μmol/kg/h)	4 hours / study day

Secondary Outcome Measures

Outcome Measure	Time Frame
13C-Phenylalanine Oxidation (μmol/kg/h)	4 hours / study day

Collaborators and Investigators

• Sponsor: University of Toronto
• Collaborators: Ajinomoto Co., Inc.

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2015
• Primary Completion (Actual): June 1, 2017
• Study Completion (Actual): June 1, 2017

Study Registration Dates

• First Submitted: December 7, 2015
• First Submitted That Met QC Criteria: December 7, 2015
• First Posted (Estimate): December 10, 2015

Study Record Updates

• Last Update Posted (Actual): December 11, 2017
• Last Update Submitted That Met QC Criteria: December 7, 2017
• Last Verified: December 1, 2017

More Information

Terms related to this study

• Other Study ID Numbers: IAAO-YF