- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03409939
Determining Total Aromatic Amino Acid Requirements in Pregnant Women
Determining Dietary Total Aromatic Amino Acid (Phenylalanine and Tyrosine) Requirements During Different Stages of Gestation in Healthy Pregnant Women
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Following a study to determine phenylalanine requirements in pregnant women, the investigator's purpose for this study is to determine the phenylalanine and tyrosine requirements (also know as the total aromatic amino acid requirement) in healthy pregnant women as part of a Doctoral Thesis project. The determined requirements can be taken into account when giving dietary recommendations, to ensure healthy pregnancies. The hypothesis is that the current recommendations for phenylalanine and tyrosine intake given to pregnant women are underestimated. The investigators also hypothesize that the phenylalanine and tyrosine requirements at early stages of pregnancy will be lower than the requirements towards the later stages of pregnancy.
Current dietary intake recommendations for the aromatic amino acids are based on factorial (mathematical) calculations and do not account for requirement differences between early and late pregnancy. Static recommendations throughout all stages of pregnancy are not appropriate because of the multitude of adaptations the human body goes through during gestation. Whether phenylalanine and tyrosine requirements differ between different stages of gestation is unknown. The DRI gives a recommendation for total aromatic amino acids of 36 mg/kg/d during pregnancy. The results from this study would allow for a more accurate recommendations in future DRIs.
The investigators will recruit healthy pregnant women aged 20 to 40 in their 13th-19th week of gestation or 33rd to 39th week of gestation. Once they get in contact with the lab, an initial visit (pre-study) will take place. Here, the participants will be measured for their eligibility and taken through the consent form. They have to participate in a pre-study for each stage of pregnancy, if they wish to participate in both stages. If they meet all the criteria and agree to participate, they will return for up to four study days per stage of 8 hours each. Therefore, if they are recruited during late pregnancy they are only able to participate in four study days in total. During these study days they will be fed protein shakes containing the stable isotope, and then oxidation of this isotope will be measured to determine a breakpoint (requirement) of phenylalanine. Breath samples, urine samples, and a small blood sample will be taken during the study day.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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British Columbia
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Vancouver, British Columbia, Canada, V6H3N1
- Clinical Research and Evaluation Unit
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- over the age of twenty
- under the age of forty
- in overall good health
- pregnant with a single child
Exclusion Criteria:
- Be under the age of twenty
- Be over the age of forty
- Be pregnant with more than one child
- Have a history of cardiovascular disease, endocrine disorders, or metabolic disorders
- Have recently lost a substantial amount of weight
- Have been pregnant with another child in the last 18 months
- Be substance dependent
- Be allergic to eggs
- Have severe nausea through the pregnancy
- Have gestational diabetes
- Have a history of spontaneous abortions
- Have had an unhealthy pre-pregnancy body mass index
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: Aromatic Amino Acid Intake
Oral consumption of eight hourly experimental meals- Includes 4 tracer-free experimental meals containing a mixture of free amino acids, calories from a flavored liquid and protein free cookies and 4- labeled amino acid experimental meals.
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Intakes will be randomly chosen from a list of 8 doses of aromatic amino acids.
Each intake will will be repeated approximately 4 times.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
13C Phenylalanine Oxidation
Time Frame: 8 hours
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Urine, breath and a single blood sample will be collected during the study to measure the rate of oxidation of 13C phenylalanine.
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8 hours
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Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Rajavel Elango, PhD, University of British Columbia
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- H17-02924
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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