Sarcopenia, Obesity, and Resistance Training

Effects of Resistance Training on Sarcopenic Obesity Index in Older Women: a RCT.

The purpose of this study was to examine the effects of resistance training on sarcopenic obesity in older women.

Study Overview

• Status: Unknown
• Conditions: Obesity; Sarcopenia; Aging
• Intervention / Treatment: Behavioral: Resistance Training

Detailed Description

To examine the effects of resistance training on sarcopenic obesity in older women, a representative sample of older women from Brasília, Brazil (n>244 subjects), will be recruited and invited to undergo body composition measurement using dual-energy x-ray absorptiometry. Moreover, the Sarcopenic Obesity index and isokinetic strength evaluations will be performed. It will be a single-blind randomized, controlled 24-week clinical trial, in which experimental group will receive a progressive resistance training program, meanwhile control group will receive instructions to maintain their lifestyle habits. Randomization will be conducted by computer-generated list in blocks of 10. Additionally, body composition, strength assessment, and sarcopenic index will collected and compared after the intervention period.

• Study Type: Interventional
• Enrollment (Anticipated): 244
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Ricardo M Lima, PhD; Phone Number: +556184908490; Email: gefsunb@gmail.com
• Study Contact Backup: Name: André B Gadelha, MSc; Phone Number: +556181880231; Email: andrebonadias@gmail.com

Study Locations

• Brazil
  • Distrito Federal
    • Brasília, Distrito Federal, Brazil, 70910900
      • Recruiting
      • Faculdade de Educação Física
      • Contact: Silvia G Neri, MSc; Phone Number: +556182055934; Email: silvia_grn@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Community older women (aged between 60 and 80 years).

Exclusion Criteria:

• individuals with any metallic implant or artificial pacemaker, who had undergone hip surgery, who were unable to walk without assistance and those affected by metabolic or endocrine disorders that affect the muscular system.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control Group; These participants will be instructed to maintain their habits during 24 weeks. Before and after the aforementioned period, they will be asked to perform body composition and strength assessments, using DXA and isokinetic dynamometer, respectively.
Experimental: Experimental group; Participants from the experimental group will assign to the resistance training program undergo physician screening at rest and under cardiopulmonary exercise test conditions before starting the program. Following a three-week familiarization process, participants undergo one repetition maximum (1-RM) testing for each of the exercises of the training program. This procedure intended to determine exercise load and will be systematically repeated in four-week intervals. Volunteers will train thrice per week during 24 weeks. The training program will involve the following exercises: chest press, lat pulldown, knee extension, hamstrings curl, leg press, hip abduction.	Behavioral: Resistance Training; 24-weeks of progressive strength training; Other Names: Strength Training

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Laboratorial Body Composition assessment (DXA)	DXA-derived body fat and DXA-derived fat free mass	30 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Isokinetic peak torque of leg extension (dynamometer isokinetic)	Dominant leg extension peak torque will be recorded in three sets of maximal effort	20 minutes

Collaborators and Investigators

• Sponsor: University of Brasilia
• Investigators: Principal Investigator: Ricardo M Lima, PhD, University of Brasilia

Study record dates

Study Major Dates

• Study Start: February 1, 2016
• Primary Completion (Anticipated): August 1, 2016
• Study Completion (Anticipated): August 1, 2016

Study Registration Dates

• First Submitted: February 10, 2016
• First Submitted That Met QC Criteria: February 10, 2016
• First Posted (Estimate): February 12, 2016

Study Record Updates

• Last Update Posted (Estimate): February 15, 2016
• Last Update Submitted That Met QC Criteria: February 11, 2016
• Last Verified: February 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Nervous System Diseases; Neurologic Manifestations; Overnutrition; Nutrition Disorders; Overweight; Body Weight; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Obesity; Sarcopenia
• Other Study ID Numbers: 487622/2012-0 (Other Grant/Funding Number: CNPq)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED