MR Perfusion Methods in Patients With Suspected Recurrent High Grade Gliomas

Accuracy of MR Perfusion Without and With Gadolinium at 3T in the Diagnosis of Patients With Suspected Recurrent High Grade Gliomas

Radiation therapy is an important adjunct in the treatment of patients with glioma, although a common side effect is radiation-induced injury of brain parenchyma. Unfortunately, conventional MRI is not accurate in differentiating radiation-induced brain injury from recurrent tumour, both of which may demonstrate progressive contrast enhancement. Recent studies have suggested that perfusion MRI could improve this differentiation. Perfusion MRI can be performed with an injection of exogenous contrast using dynamic contrast enhancement (DCE) or dynamic susceptibility contrast enhancement (DSC). Perfusion MRI can also be performed without contrast injection using arterial spin labeling (ASL) or intravoxel incoherent motion (IVIM). DCE-MRI relies on accurate measurement of T1 values in order to convert the MRI signal intensity to contrast concentration. Dynamic susceptibility-weighted contrast enhancement (DSC) perfusion is the most common technique used in clinical practice but measurement of tumor relative cerebral blood volume (rCBV) can be biased by extravascular contrast leakage and susceptibility-weighted artifacts. The purpose of this study is to evaluate the accuracy of perfusion MR imaging using non-contrast and contrast-based techniques in differentiating recurrent tumour from radiation-induced brain injury in patients with known high grade glioma. The investigators will compare the accuracy of IVIM, ASL, DCE and DSC techniques. A secondary goal of the study is to compare two new different T1 mapping methods used for DCE-MRI.

Study Overview

• Status: Completed
• Conditions: Glioma
• Intervention / Treatment: Device: MR perfusion imaging

Detailed Description

The aim of this study is to evaluate the diagnostic accuracy of different MR perfusion methods in differentiating recurrent tumour from radiation-induced brain injury in patients with high grade gliomas. The investigators will evaluate perfusion methods which do not use an exogenous agent (ASL, IVIM) and methods which use gadolinium as a contrast agent (DSC-MRI, DCE-MRI).

A secondary goal of the study is to compare two new different T1 mapping methods used for DCE-MRI. The first T1 mapping method uses a Lock-Locker inversion-recovery acquisition (MOLLI) that measures apparent T1 (T1*). The second T1 mapping method uses a single-point, saturation-recovery acquisition that measures true T1 SMART1Map.

This study is a prospective study which will involve 50 patients.

Patients who have received chemoradiation for high grade gliomas and who subsequently developed progressive enhancing lesions on follow-up MR will be asked to participate in this study. Informed consent by the patient or a legal guardian or authorized representative of the patient will be obtained before enrollment.

Following enrollment, MR perfusion imaging (ASL, IVIM, DSC and DCE perfusion sequences) will be performed in addition to the routine neuronavigational sequence obtained fror re-operative/ therapy planning.

Following this MR examination, the patient may undergo a surgical biopsy or excision as determined clinically by the neurosurgeon. The location of the biopsy will be saved intraoperatively which will allow colocalization of histopathology with imaging data. Histopathological analysis will be performed by the neuropathologist, yielding a visual quantitative estimate of percent viable tumour and radiation necrosis within the obtained specimen.

All patients, including those who do not go to surgery, will undergo clinical followup and imaging follow-up with perfusion imaging. This will allow for assessment of lesion progression over time, yielding valuable diagnostic information in differentiating radiation necrosis from tumour recurrence, particularly in those patients who did not undergo surgery.

Following a routine clinical MR examination, patients with a new lesion or an enlarging lesion will be seen by the radiation oncologist or neurosurgeon. They will be recruited by a research nurse who will ask if they are willing to participate in the research study. If the patient agrees to participate, the investigators will add perfusion sequences in addition to the clinical MR exam for treatment planning (stereotactic radiation or reresection). The MR exam performed for clinical and research purposes will last less than 45 minutes. Following surgery, the investigators will correlate pathological findings with perfusion and diffusion parameters. If the patient does not undergo surgery, we will use clinical examination and serial MRIs (including perfusion imaging) to determine if the index lesion is more likely to represent radiation necrosis or tumor progression. The investigators will follow the patient clinically for 2 years after the time of progression to determine overall survival.

Patients with high grade gliomas are followed routinely with serial MRIs. The patients with progressive enlarging lesions will be seen by the treating oncologist or neurosurgeon.

They will electronically put in a request for another MR exam which is needed clinically for surgical planning and/or follow-up with advanced MR imaging as per standard of care.

When the patient comes to radiology for their exam, they will be asked to participate in the study by the radiologist and/or the research nurse (if this breaches patient confidentiality, we can put the radiologist as the person getting consent since he is involved in patient care). If the patient agrees to participate, the study will be performed according to the study MR protocol. If not, a standard MRI as per routine clinical practice will be performed. The investigators do not intend to recruit patients who are unable to give consent themselves since patients have to have a good Karnofsky score as an inclusion criteria in this study.

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Ontario
    • Ottawa, Ontario, Canada, K1Y1J7
      • The Ottawa Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Patients enrolled must have:

1. Had a diagnosis of high grade glioma and had received chemoradiation
2. Developed a new lesion or an increase size of their treated lesion on follow-up MRI (either on post contrast T1W images or on FLAIR)
3. Karnofsky performance status (kps) score >70 (potential candidate for reresection of stereotactic radiation)

Exclusion Criteria:

1. Patients under 18 years of age
2. Pregnant patients (for women of child bearing potential - a negative serum beta HCGT is required).
3. Known or suspected allergies to gadolinium-based contrast agents.
4. Patients with chronic or acute renal insufficiency (glomerular filtration rate < 30 mL/min/1.73m2), including acute renal insufficiency of any severity due to hepatorenal syndrome or in the perioperative liver transplantation period.
5. General contraindications to MRI such as pacemaker or ferromagnetic implants.
6. Severe cardiovascular disease
7. Intractable seizures while on adequate anticonvulsant therapy (more than one seizure per month for the past 2 months)
8. Sickle-cell anaemia or other known hemoglobinopathies, or other forms of haemolytic anaemia

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: NA
• Interventional Model: SINGLE_GROUP
• Masking: NONE

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

OTHER: MRI perfusion imaging; Patients who have received chemoradiation for high grade gliomas and who subsequently developed progressive enhancing lesions on follow-up MR will be asked to participate in this study.

Device: MR perfusion imaging; MR perfusion imaging will be performed in addition to the routine neuronavigational sequence obtained from re-operative/therapy planning. Following MR examination, patient may undergo a surgical biopsy or excision as determined clinically by the neurosurgeon. All patients, including those who do not go to surgery, will undergo clinical follow-up and imaging follow-up with perfusion imaging. This will allow for assessment of lesion progression over time, yielding valuable diagnostic information in differentiating radiation necrosis from tumour recurrence, particularly in those patients who do not undergo surgery.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Estimate the Receiver Operating Characteristic (ROC) curve	Estimate the Receiver Operating Characteristic (ROC) curve for the assessment of the diagnostic accuracy of f, CBF, CBV, Cp and Ktrans, obtained from different MR perfusion acquisition methods for distinguishing recurrent tumour from radiation necrosis.	up to 22 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Different T1 mapping methods used for DCE-MRI will be compared to the current gold standard	Different T1 mapping methods used for DCE-MRI (MOLLI that measures apparent T1 and SMARTMap that measures true T1) will be compared to the current gold standard (inversion recovery).	up to 22 months

Collaborators and Investigators

• Sponsor: Ottawa Hospital Research Institute

Study record dates

Study Major Dates

• Study Start (ACTUAL): December 13, 2017
• Primary Completion (ACTUAL): August 3, 2021
• Study Completion (ACTUAL): August 3, 2021

Study Registration Dates

• First Submitted: July 13, 2016
• First Submitted That Met QC Criteria: September 27, 2016
• First Posted (ESTIMATE): September 29, 2016

Study Record Updates

• Last Update Posted (ACTUAL): October 8, 2021
• Last Update Submitted That Met QC Criteria: October 7, 2021
• Last Verified: October 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue; Glioma
• Other Study ID Numbers: 20160425-01H

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No