Gender-specific Associations Between Quality of Life and Leukocyte Telomere Length

Gender-specific Associations Between Quality of Life and Leukocyte Telomere Length: A Cross-sectional Study

Quality of life (QoL) is an important factor for successful aging. Telomere length is an indicator of cellular aging and cumulative biological stress and is thus related to health status and survival. However, the relationship between QoL and telomere length has not yet been examined. In this study we investigated the relationship between leukocyte telomere length (LTL) and QoL.

However, the relationship between overall QoL and LTL has not previously been investigated. Therefore, this study was conducted to examine the relationship between LTL and QoL. QoL was measured by the Korean version of the 36-item short-form health survey (SF-36), which is a multidimensional scale consisting of subjective evaluation.

Study Overview

• Status: Completed
• Conditions: Apparently Healthy People Aged 55 and Over
• Intervention / Treatment: Other: quality of life

• Study Type: Observational
• Enrollment (Actual): 164

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 55 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

A total of 164 apparently healthy subjects (82 couples) aged 55 and over were included in this study.

Description

Inclusion Criteria:

• married couple
• apparently healthy subjects above 55 years

Exclusion Criteria:

• Subjects who had experienced hormone therapy
• Subjects who had been diagnosed with dementia, Parkinson's disease, stroke, ischemic heart disease, congestive heart failure, arrhythmia, depression, cancer, thyroid disorders, or chronic renal disease

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
leukocyte telomere length	Leukocyte telomere length was measured as telomere repeat copy number relative to single gene copy number by quantitative real-time PCR	8months

Collaborators and Investigators

• Sponsor: Jung-Ha Kim

Study record dates

Study Major Dates

• Study Start (Actual): October 25, 2013
• Primary Completion (Actual): October 24, 2014
• Study Completion (Actual): October 24, 2014

Study Registration Dates

• First Submitted: May 11, 2017
• First Submitted That Met QC Criteria: May 11, 2017
• First Posted (Actual): May 12, 2017

Study Record Updates

• Last Update Posted (Actual): May 12, 2017
• Last Update Submitted That Met QC Criteria: May 11, 2017
• Last Verified: May 1, 2017

More Information

Terms related to this study

• Other Study ID Numbers: C 2013152(1112)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No