Search clinical trials for: bile acids

Total 9943 results

Sanjiv Harpavat
Baylor College of Medicine

Not yet recruiting

Tolerability of Enteral NAC in Infants

Biliary Atresia
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Role of Bile Acids and Microbiota in Clostridioides Difficile Infection in Ulcerative Colitis (ABRICO)

Ulcerative Colitis

France
St. Boniface Hospital

Not yet recruiting

Impact of Therapy Using Colesevelam Treatment Reducing Bile Acids in Patients With Fontan Circulation. (MYSTIC)

Fontan Circulation
POLYSAN Scientific & Technological Pharmaceutical...

Recruiting

Comparative Study of REMAXA®, Enteric-coated Tablets and REMAXOL®, Solution for Infusions, in Intrahepatic Cholestasis

Cholestasis, Intrahepatic

Russian Federation
Region Stockholm
Amgen

Not yet recruiting

Studies to Gain Insight How the Drugs PCSK9-inhibitors and Statins Affect Cholesterol and Bile Acid Metabolism

Acute Metabolic Effects of Evolocumab and Atorvastatin
Air Force Military Medical University, China

Recruiting

A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles

Bile Duct Diseases | Bile Duct Neoplasms | Jaundice, Obstructive

China
Medical University of Warsaw
National Science Centre, Poland

Recruiting

S-adenosylmethionine (SAMe) in Patients With Primary Sclerosing Cholangitis (PSC)

Primary Sclerosing Cholangitis (PSC)

Poland
Humanitas Mirasole SpA
KU Leuven; UMC Utrecht; University of Sheffield; Istituto Superiore di Sanità; University... and other collaborators

Recruiting

Open Label Extension of TUDCA-ALS Study (TUDCA-ALS OLE)

Amyotrophic Lateral Sclerosis

Germany, France, Netherlands, Italy, United Kingdom, Belgium, Ireland
Postgraduate Institute of Medical Education and...

Recruiting

Bile Acids Metabolism and Genetic Mutation Profile in the ICP in the Indian Population (ICP)

Intrahepatic Cholestasis of Pregnancy | Genetic Mutation | Health Related Quality of Life

India
Columbia University

Recruiting

Bile Acids in Acute Insulin Resistance

Cancer | Insulin Resistance | MTOR Gene Mutation | PI3K Gene Mutation | AKT Gene Mutation

United States
Columbia University
National Cancer Institute (NCI); Weill Medical College of Cornell University

Recruiting

The Microbiome, Bile Acids, and Notch in Barrett's Esophagus (BE)

Barrett Esophagus | Esophageal Adenocarcinoma

United States
Montana State University

Recruiting

Impact of Foods on Bile Acids, Metabolites, and Inflammation

Inflammation | Hyperlipidemias | Hypertriglyceridemia | Metabolic Disease | Bile Acid Malabsorption | Lipid Metabolism Disorder

United States
Peking University Third Hospital

Recruiting

the Association of Intestinal Microbial Metabolites and Cardiac Function in Acute Myocardial Infarction

Acute Myocardial Infarction

China
University Hospital, Lille

Not yet recruiting

Evaluation of Cortisol and Bile Acids Metabolism in Obese Patients (CORTABO)

Obesity
Mats Heyman
Assistance Publique - Hôpitaux de Paris; Karolinska Institutet; Pfizer; The Swedish... and other collaborators

Recruiting

A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

Leukemia, Acute Lymphoblastic

Belgium, United Kingdom, Denmark, Germany, Portugal, Netherlands, Estonia, France, Finland, Iceland, Norway, Sweden, Lithuania, Ireland
Peking Union Medical College Hospital
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

Toripalimab Plus Lenvatinib as Second-line Treatment in Advanced Biliary Tract Cancers

Advanced Biliary Tract Cancer

China
Population Health Research Institute
Hamilton Health Sciences Corporation

Recruiting

Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery (ASPIRE-AF)

Stroke | Atrial Fibrillation

Canada, Australia, Germany, Denmark, Switzerland, Spain, Korea, Republic of, New Zealand, India, Netherlands, Argentina, United Kingdom, Brazil, Italy, Nepal, Sweden, Pakistan
Stanford University

Recruiting

The Role of Secondary Bile Acids in Intestinal Inflammation

Ulcerative Colitis | Pouchitis

United States
Shandong Provincial Hospital

Recruiting

The Biological Rhythm of Human Metabolite

Metabolism and Nutrition Disorder | Rhythm Nodal | Metabolism Disorder, Lipid

China
National Cancer Institute (NCI)

Active, not recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Glioma | Hematopoietic and Lymphoid Cell Neoplasm | Melanoma | Lymphoma | Multiple Myeloma | Recurrent Ovarian Carcinoma | Breast Carcinoma | Recurrent Head and Neck Carcinoma | Recurrent Lung Carcinoma | Recurrent Skin Carcinoma | Gastric Carcinoma | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory... and other conditions

United States, Puerto Rico, Guam
Xuzhou Medical University

Completed

The Impact of Different Exercise Modes on Bile Acid Levels and Liver Function in Patients With Non-alcoholic Fatty Liver Disease

Non-alcoholic Fatty Liver Disease NAFLD

China
Celldex Therapeutics
Merck Sharp & Dohme LLC

Completed

A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies

Melanoma | Follicular Lymphoma | Renal Cell Carcinoma | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Pancreatic Adenocarcinoma | Ovarian Cancer | Fallopian Tube Cancer | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Lymphoplasmacytic Lymphoma | Non-Hodgkin Lymphoma | ... and other conditions

United States
Baylor College of Medicine

Completed

N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy

Biliary Atresia

United States
Instituto Nacional de Ciencias Medicas y Nutricion...

Completed

Modulation of Secondary Bile Acids Through the Intestinal Microbiota After Consumption of a High-protein Diet.

Healthy

Mexico
Mayo Clinic
Multiple Myeloma Research Foundation

Completed

Venetoclax, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma

Recurrent Plasma Cell Myeloma | t(11;14)

United States
University of Illinois at Chicago
National Cancer Institute (NCI); Rush University Medical Center

Active, not recruiting

Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colon Cancer Risk

Colorectal Cancer

United States
The Royal Wolverhampton Hospitals NHS Trust

Completed

The Role of Faecal Bile Acids in the Management of Bile Acid Diarrhoea

Bowel Diseases

United Kingdom
Mirum Pharmaceuticals, Inc.
Children's Hospital Medical Center, Cincinnati

Completed

Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid

Cholestasis | Peroxisomal Disorders | Adrenoleukodystrophy | Zellweger Syndrome | Infantile Refsum's Disease

United States
Mirum Pharmaceuticals, Inc.

Completed

Efficacy of To Be Marketed (TBM) Cholic Acid Capsules Used to Treat Children With Inborn Errors of Bile Acid Synthesis

Inborn Errors of Bile Acid Synthesis

United States
Mirum Pharmaceuticals, Inc.

Completed

Open Label, Continuation Study of Cholic Acid in Subjects With Inborn Errors of Bile Acid Synthesis

Bile Acid Synthesis Defect

United States
University of Nebraska

Terminated

Sulfation of Bile Acids as a Biomarker for Hepatobiliary Diseases

Hepatobiliary Diseases

United States
University of Nebraska

Completed

The Effect of Sleeve Gastrectomy on Post-prandial Serum Bile Acids (BAS)

Obesity

United States
Charles University, Czech Republic
University of Roma La Sapienza; University Of Perugia; Iscare i.v.f., Czech Republic and other collaborators

Active, not recruiting

The Effect of VSL#3 Probiotic Preparation on the Bile Acid Metabolism in Patients With Inflammatory Bowel Disease

Crohn Disease | Ulcerative Colitis

Czechia
Indiana University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Active, not recruiting

Irritable Bowel Syndrome and Control Volunteers: Diet Challenge

IBS - Irritable Bowel Syndrome

United States
RWTH Aachen University

Completed

Dietary Modulation of Intestinal Microbiota as Trigger of Liver Health: Role of Bile Acids - "A Diet for Liver Health" (ADLH)

NASH - Nonalcoholic Steatohepatitis

Sweden, Austria, Germany
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Enrolling by invitation

Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With Obesity and Abnormal Satiety Phenotype

Healthy | Obesity

United States
Mayo Clinic
Satiogen Pharmaceuticals, Inc.

Completed

Ox Bile- Conjugated Bile Acids Sodium in Type II Diabetes Mellitus

Overweight | Type 2 Diabetes Mellitus | Obese

United States
University of Oxford
Oregon Health and Science University; University of Washington; University of... and other collaborators

Active, not recruiting

Pancreatic Enzymes and Bile Acids in Acutely Ill Severely Malnourished Children (PB-SAM)

SEPSIS | MALNUTRITION, CHILD

Bangladesh, Uganda, Malawi, Kenya
Mirum Pharmaceuticals, Inc.

Terminated

A Placebo-controlled Study of Volixibat in Subjects With Elevated Serum Bile Acids Associated With Intrahepatic Cholestasis of Pregnancy (OHANA) (OHANA)

Intrahepatic Cholestasis of Pregnancy

United States, United Kingdom, New Zealand
Children's Hospital Medical Center, Cincinnati

Completed

GlycoCholic Acid Treatment for Patients With Inborn Errors in Bile Acid Synthesis

Bile Acid Synthesis Defect | Inborn Error of Bile Acid Metabolism | Inborn Error of Bile Acid Conjugation

United States
Fundació Institut de Recerca de l'Hospital de la...
AB Biotics, SA

Completed

Probiotic Intervention, Bile Acids and Lipid Metabolism Metabolic Profile in Healthy Overweight Subjects. (PROBILIP)

Probiotic Intervention

Spain
University of Washington

Completed

Afatinib Dimaleate and Capecitabine in Treating Patients With Advanced Refractory Solid Tumors, Pancreatic Cancer or Biliary Cancer

Advanced Malignant Solid Neoplasm | Recurrent Pancreatic Carcinoma | Stage III Pancreatic Cancer AJCC v6 and v7 | Recurrent Malignant Solid Neoplasm | Stage IVA Pancreatic Cancer | Stage IVB Pancreatic Cancer | Bile Duct Carcinoma

United States
University of Aarhus
GE Healthcare; Danish Cancer Society

Completed

The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon

Diarrhea | Colon Adenocarcinoma

Denmark
Chang Gung Memorial Hospital

Unknown

Gut Microbiota and Bile Acids in Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2 | Metformin | YH1

Taiwan
Hvidovre University Hospital
University of Copenhagen

Completed

Effect of Bile Acids and Bile Acid Sequstrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass

Severe Obesity

Denmark
Hvidovre University Hospital
University of Copenhagen

Completed

Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass

Severe Obesity

Denmark
Children's Hospital Medical Center, Cincinnati
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Intralumenal Effects on Cholesterol Absorption/Synthesis

Healthy

United States
Sahlgrenska University Hospital, Sweden

Unknown

Obeticholic Acid in Morbidly Obese Patients and Healthy Volunteers (OCAPUSH)

Obesity

Sweden
National Institute of Diabetes and Digestive and...

Completed

Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)

Healthy Volunteers

United States
GlaxoSmithKline

Completed

Daprodustat Bioequivalence and Food Effect Study

Anaemia

Japan

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