Locally Injected Vit D as a Non-surgical Modality for Periodontal Regeneration of Infrabony Defects

Locally Injected Vitamin D as a Non-surgical Modality for Periodontal Regeneration of Infrabony Defects: Prospective Study

vitamin D has great role in bone regenration and soft tissue health. in the past periodontal regeneration was performed using bone graft and barrier membrane

Study Overview

• Status: Completed
• Conditions: Periodontal Bone Loss; Periodontal Pocket
• Intervention / Treatment: Dietary supplement: locally injected vitamin D

Detailed Description

there was no previous studies used the locally injected vitamin d in periodontal regeneration. therefore, we intended to study the effect of locally injected vitamin D in peridoontal regerneration in comparison with the conventional surgical technique

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• patients with infrabony vertical defects
• systemically free patients
• periodontally affected patients

Exclusion Criteria:

• patients with systemic diseases
• smokers
• pregnency

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: non-surgical periodontal regeneration; non-surgical periodontal regeneration using locally injected vitamin d to treat the infrabony defect	Dietary supplement: locally injected vitamin D; locally injected vitamin d as non surgical method for periodontal regeneration of vertical bony defects; Other Names: non-surgical periodontal rgeneration
Active Comparator: surgical peridoontal regeneration; surgical periodontal regeneration using bone graft and collagen barrier	Dietary supplement: locally injected vitamin D; locally injected vitamin d as non surgical method for periodontal regeneration of vertical bony defects; Other Names: non-surgical periodontal rgeneration

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
radiographic interproximal bone level	radiographic interproximal bone level	6 months

Collaborators and Investigators

• Sponsor: Cairo University
• Investigators: Study Director: nermin yussif, October University of Modern Sciences and Arts

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2016
• Primary Completion (Actual): January 1, 2018
• Study Completion (Actual): June 1, 2018

Study Registration Dates

• First Submitted: October 13, 2018
• First Submitted That Met QC Criteria: October 22, 2018
• First Posted (Actual): October 23, 2018

Study Record Updates

• Last Update Posted (Actual): October 23, 2018
• Last Update Submitted That Met QC Criteria: October 22, 2018
• Last Verified: October 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Musculoskeletal Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Bone Diseases; Periodontal Atrophy; Bone Resorption; Periodontitis; Alveolar Bone Loss; Periodontal Pocket; Physiological Effects of Drugs; Micronutrients; Vitamins; Bone Density Conservation Agents; Vitamin D
• Other Study ID Numbers: 1236

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No