Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives

September 18, 2020 updated by: Zeki Çetinkaya, TC Erciyes University

Comparison of the Severity and Prevalence of Coronary Atherosclerosis With Tissue Compliance (HLA Similarity ) in Patients Within First Degree Relatives

This study research the similarity of coronary artery lesions according to HLA tissue compatibility in fisrt degree relatives of the patients who just admitted clinic as Acute coronary syndrome and underwent angiyography before .

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Coronary artery disease (CAD), which is mainly caused by atherosclerosis, is the most prevalent illness and the leading cause of death worldwide. Increasing evidence suggests that inflammation plays a primordial role in atherogenesis and is closely associated with the major histocompatibility complex (MHC) (human leukocyte antigen [HLA] in humans) molecules. HLA genes are located in 6p21.3, the proteins encoded by these HLA genes have a major role to play in antigen presentation and inflammatory pathways. HLA involvement in inflammation is mainly associated with the HLA-dependent activation of T cells. studies reported that the susceptibility to CAD is related with the polymorphisms in HLA-DRB1. The above evidence indicates that the polymorphisms in HLA class II are associated with the risk of CAD . This study research investigate three objects , firstly what is the similarity of the coronary artery lesions according to the compatability of HLA alleles between the first degree relatives who went angiography before , secondly is there any relation between HLA subtype allels and the coronary artery (RCA ?LAD ? ,CX? and can such a relation be responsible from the lesions in this artery ,finally is there any relation between HLA subtypes and turkish race coronary artery disease

Study Type

Observational

Enrollment (Anticipated)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
    • Melikgazi
      • Kayseri, Melikgazi, Turkey, 38200

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

  • male or female with age between 18-70
  • hospital admission due to acute coronary syndrome with first degree relative history who had coronary angiyography before

Description

Inclusion Criteria:

  • male or female with age between 18-70
  • hospital admission due to acute coronary syndrome with first degree relative history who had coronary angiyography before

Exclusion Criteria:

  • first degree relative without any angiyography history before for patients who admitted as acute coronary syndrome

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
relation between HLA subgroups and severity and prevelance of coronary artery lesions
Time Frame: 20 MAY 2019 - 30 MAY 2019
the hla similarity of two sibling patient %80 and the military syntax score %97,7
20 MAY 2019 - 30 MAY 2019

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

TC Erciyes University

Investigators

  • Study Director: Zeki Çetinkaya, doctor

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

September 18, 2020

Primary Completion (Anticipated)

December 7, 2020

Study Completion (Anticipated)

January 1, 2021

Study Registration Dates

First Submitted

May 28, 2019

First Submitted That Met QC Criteria

June 29, 2019

First Posted (Actual)

July 2, 2019

Study Record Updates

Last Update Posted (Actual)

September 21, 2020

Last Update Submitted That Met QC Criteria

September 18, 2020

Last Verified

September 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2018/543

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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