Molecular Mechanisms of Tooth Eruption

The main objective is to study the expression of molecules involved in tooth morphogenesis and eruption in healthy patients, and then to compare them with the results in patients with abnormalities of eruption (results obtained via a collection of biological samples of rare diseases already authorized).

Study Overview

• Status: Not yet recruiting
• Conditions: Tooth Eruption
• Intervention / Treatment: Procedure: Tooth extraction

• Study Type: Observational
• Enrollment (Anticipated): 50

Contacts and Locations

• Study Contact: Name: Marion STRUB; Phone Number: +33 3 88 69 56; Email: marion.strub@chru-strasbourg.fr

Study Locations

• France
  • Strasbourg, France, 67091
    • Les Hôpitaux Universitaires de Strasbourg
    • Contact: Marion STRUB; Phone Number: +33 3 88 69 56; Email: marion.strub@chru-strasbourg.fr
    • Principal Investigator: Marion STRUB

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years and older (ADULT, OLDER_ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Primary care clinic (Hôpitaux Universitaires de Strasbourg, France)

Description

Inclusion Criteria:

• Patient over 12 years old who has given his consent
• Patient whose legal representatives have given their consent for the use of operating waste destined for incineration
• Patient undergoing oral surgery at the University Hospitals of Strasbourg, at the origin of the production of surgical waste such as teeth and bone fragments
• Patient affiliated to a social security system

Exclusion Criteria:

• Refusal to participate
• Patient with chronic systemic pathology
• Patient under long-term drug treatment
• Patient presenting a rare pathology with oral manifestation
• Patient with a history of chemotherapy or head and neck radiotherapy
• Non-French speaking patient / inability to give informed information
• Patient under guardianship, curatorship or legal protection

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Normal tooth eruption	Procedure: Tooth extraction; Tooth extraction

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Expression and localization of molecules involved in tooth eruption	Tissues are collected at the time of surgery and transferred during the day to the laboratory for analysis	During surgery

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France

Study record dates

Study Major Dates

• Study Start (ANTICIPATED): March 1, 2021
• Primary Completion (ANTICIPATED): March 1, 2021
• Study Completion (ANTICIPATED): January 1, 2023

Study Registration Dates

• First Submitted: December 14, 2020
• First Submitted That Met QC Criteria: December 14, 2020
• First Posted (ACTUAL): December 19, 2020

Study Record Updates

• Last Update Posted (ACTUAL): March 30, 2021
• Last Update Submitted That Met QC Criteria: March 29, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases; Exanthema
• Other Study ID Numbers: 7946

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No