Comparison of the Swallowing Functions in Sarcopenia and Dynapenia

Comparison of the Swallowing Functions of the Sarcopenia and Dynapenia Patients

The purpose of the study to investigate the comparison of the swallowing functions of the sarcopenia and dynapenia in older patients

Study Overview

• Status: Active, not recruiting
• Conditions: Sarcopenia; Dysphagia; Swallowing Disorder

Detailed Description

Sarcopenia is a geriatric syndrome; from skeletal muscle, and in its usefulness. Dynapenia is a picture of sarcopenia without measurable muscle mass. It has been shown that dysphagia complaints are more common in patients with sarcopenia than in the normal population, but a comparison with patients with dynapenia has not been made to the best of our knowledge. According to the algorithm of The International Society of Physical and Rehabilitation Medicine (ISPRM), experts in the special interest group on sarcopenia, in the routine examination of patients aged 60-90 years who applied to the Physical Medicine and Rehabilitation outpatient clinic with complaints of decreased muscle function, weakness, and slow movement, or "sarcopenia" or Patients with "dynapenia" and patients without Sarcopenia disease who volunteered to participate in the study will be included in the order of application to the outpatient clinic.

• Study Type: Observational
• Enrollment (Actual): 108

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey, 34384
    • Prof Dr Cemil Tascioglu City Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 56 years to 86 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients who were 60-90 years old.

Description

Inclusion Criteria:

• Age between 60-90 years
• Sarcopenia and dynapenia patients in study groups
• Non- sarcopenia and non-dynapenia patients in control groups
• Patients who were accept to consent form

Exclusion Criteria:

• Severe sarcopenia patients
• Cognitive limitations
• Out of age 60-90 years old
• Patients who were not accept to consent form

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Crossover
• Time Perspectives: Prospective

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort
Group A; Sarcopenia patients.
Group B; Dynapenia patients.
Group C; Age and gender matched non-sarcopenia and non-dynapenia patients.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The values of Pharyngeal Residue Severity	It was assessed with Fiberoptic Endoscopic Evaluation of Swallowing. Fiberoptic Endoscopic Evaluation of Swallowing results were scored on Yale Pharyngeal Residue Severity Rating scale. The scores of scale were none, trace, mild, moderate, and severe. The high-grade symptom scores were worst, low scores were good swallowing functions.	Baseline
The values of penetration and aspiration	It was assessed with Fiberoptic Endoscopic Evaluation of Swallowing. Fiberoptic Endoscopic Evaluation of Swallowing results were scored on the Penetration and aspiration scale. The scores of scale were between 1-8 points. The high points were worst, low points were good swallowing functions.	Baseline
The evaluation of eating and swallowing functions	They were assessed by Eating Assessment Tool in participants. Composite Score ranges from 0 ( good) to 4 (worst). The minimum total score was 0 and the maximum total score was 40. The cut-off value was 3 points. High scores show worst eating and swallowing functions, and low quality of life.	Baseline
The evaluation of depression	They were assessed by Geriatric Depression Scale in participants. The scores between 0-10 were no depression, between 11-13 points were probably depression, and higher of 14 points were exact depression.	Baseline
The values of muscle strength	They were assessed as newton by hand grip device.	Baseline
The values of muscle mass	The diameters of tigh were measured with tailor meter by a Physical Medicine and Rehabilitation professionals (measure unit is cm).	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mean of demographic	Age, gender, history of smoke, history of morbidities, diagnosis, stage, were noted	Baseline

Collaborators and Investigators

• Sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
• Investigators: Principal Investigator: yavuz atar, Asso Prof,MD, Prof. Dr. Cemil Taşcıoğlu City Hospital

Publications and helpful links

General Publications

• Firat Ozer F, Akin S, Soysal T, Gokcekuyu BM, Erturk Zararsiz G. Relationship Between Dysphagia and Sarcopenia with Comprehensive Geriatric Evaluation. Dysphagia. 2021 Feb;36(1):140-146. doi: 10.1007/s00455-020-10120-3. Epub 2020 Apr 27.
• Kara M, Kaymak B, Frontera W, Ata AM, Ricci V, Ekiz T, Chang KV, Han DS, Michail X, Quittan M, Lim JY, Bean JF, Franchignoni F, Ozcakar L. Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM. J Rehabil Med. 2021 Jun 21;53(6):jrm00209. doi: 10.2340/16501977-2851.
• Chen YC, Chen PY, Wang YC, Wang TG, Han DS. Decreased swallowing function in the sarcopenic elderly without clinical dysphagia: a cross-sectional study. BMC Geriatr. 2020 Oct 21;20(1):419. doi: 10.1186/s12877-020-01832-0.

Study record dates

Study Major Dates

• Study Start (Actual): July 26, 2021
• Primary Completion (Anticipated): August 27, 2021
• Study Completion (Anticipated): August 27, 2021

Study Registration Dates

• First Submitted: July 2, 2021
• First Submitted That Met QC Criteria: July 2, 2021
• First Posted (Actual): July 13, 2021

Study Record Updates

• Last Update Posted (Actual): August 25, 2021
• Last Update Submitted That Met QC Criteria: August 21, 2021
• Last Verified: August 1, 2021

More Information

Terms related to this study

• Keywords: sarcopenia; dysphagia; swallowing; deglutition; dynapenia
• Additional Relevant MeSH Terms: Digestive System Diseases; Nervous System Diseases; Neurologic Manifestations; Gastrointestinal Diseases; Pharyngeal Diseases; Otorhinolaryngologic Diseases; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Esophageal Diseases; Muscular Atrophy; Atrophy; Sarcopenia; Deglutition Disorders
• Other Study ID Numbers: 261

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No