Overactive Bladder Syndrome

The Role of Primary Nocturnal Enuresis in the Etiology of Overactive Bladder Syndrome

Purpose:

A lot of etiological factors related to overactive bladder (OAB) has been investigated. However, the role of primary nocturnal enuresis (NE), which is characterized with childhood night time incontinence, in the etiology of OAB is controversial. This study aims to evaluate the effect of NE in patients diagnosed with OAB.

Metod Between january-september 2021, the data of patients who applied to the urology outpatientclinic with OAB symptoms were collected. Patients with a history of chronic systemic disease, previous medical treatment for OAB and who did not accept to join the study were excluded. According to the diagnosis of childhood NE, patients were divided into two groups. Demographic data hav been recorded. Frequency of incontinence, number of day time void and nocturia were evaluated according to a 3 day voiding diary. Inaddition, max. Urinary flowr atio (Qmax), bladder Wall thickness and postvoid residual volüme rates were determined using uroflowmetry and pelvic ultrasound.

Study Overview

• Status: Completed
• Conditions: Overactive Bladder Syndrome; Enuresis, Nocturnal
• Intervention / Treatment: Other: basicly

Detailed Description

A prospective randomized study is a study based on basic urological data. This study aims to evaluate the effect of NE in patients diagnosed with OAB.

• Study Type: Observational
• Enrollment (Actual): 87

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey, 34768
    • Hisar Intercontinental Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

up to 18 year and all sex

Description

Inclusion Criteria:

• overactive bladder syndrome
• enuresis nocturna

Exclusion Criteria:

• diabetes mellitus,
• neurological diseases
• bladder outlet obstruction,
• active urinary system infection

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Enuresis, Non-Enuresis; Patients were divided into two gruops according to whether having NE or not during childhood	Other: basicly; Do not repeat information already included in arm/group descriptions.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
A diagnose of childhood NE in OAB patients can cause more severe semptomatologic progression	This study aims to evaluate the effect of NE in patients diagnosed with OAB.Definition of NE is urinary incontinence in children over the age of 5 during sleep ,as defined by International Children's Continence Society. Overactive Bladder Symptom Score (OABSS) questionnaire were used for the assessment of OAB. OABSS is an questionnaire ,consisting of 4 questions, was prepared by Homma et al. in 2006	1 years

Collaborators and Investigators

• Sponsor: Hisar Intercontinental Hospital
• Investigators: Study Chair: Basri Cakiroglu, Hisar Intercontinental Hospital

Study record dates

Study Major Dates

• Study Start (Actual): February 3, 2020
• Primary Completion (Actual): July 3, 2021
• Study Completion (Actual): October 15, 2021

Study Registration Dates

• First Submitted: November 11, 2021
• First Submitted That Met QC Criteria: November 25, 2021
• First Posted (Actual): December 9, 2021

Study Record Updates

• Last Update Posted (Actual): December 9, 2021
• Last Update Submitted That Met QC Criteria: November 25, 2021
• Last Verified: November 1, 2021

More Information

Terms related to this study

• Keywords: treatment; Overactive bladder; etiology; Enuresis nocturna
• Additional Relevant MeSH Terms: Behavioral Symptoms; Mental Disorders; Pathologic Processes; Urologic Diseases; Urinary Bladder Diseases; Lower Urinary Tract Symptoms; Urological Manifestations; Disease; Urination Disorders; Elimination Disorders; Urinary Bladder, Overactive; Syndrome; Urinary Incontinence; Enuresis; Nocturnal Enuresis
• Other Study ID Numbers: 2020/04

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No