- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05228639
COVID-19 Surveillance in Rural Mozambique for Prompt and Effective Response (MozCOVID)
Coronavirus Disease 2019 Surveillance in Manhiça District Southern Mozambique for a Prompt and Effective Response Against the Epidemic
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
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Manhica, Mozambique
- Centro de Investigaçao em Saúde de Manhiça
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria The study has five components and therefore the inclusion criteria may vary from one component to another.
COVID-19 morbidity surveillance
- Individuals of any age admitted to MDH or pregnant attending the Maragra health center meet the COVID-19 case definition as defined above after the project start date.
- Resident of Manhiça DSS area
- Written informed consent from a parent or guardian if a child, and from participant if an adult prior recruitment.
COVID-19 mortality surveillance • All deaths in children under the age of 5 (including stillbirths), occurring at the health facility or at the community; • In hospital adult deaths occurring at the MDH;
• Resident of Manhiça DSS area;
• Written informed consent from the relative of the dead person.
- COVID-19 population-based serosurveys • Individuals of all age groups residing in Manhiça DSS surveillance area • Signed informed parental permission from a parent or guardian if a child and from participant if an adult.
Natural history of SARS-CoV-2 infection
• Participants who fulfill eligibility criteria for activity a) and with laboratory-confirmed SARS-CoV-2 infection.
- Clinical presentation and factors associated with SARS-CoV-2 • Participants who fulfill eligibility criteria for activities a) and c).
Exclusion Criteria
• Participation in an interventional clinical trial at the time of enrollment.
Study Plan
How is the study designed?
Design Details
- Observational Models: Other
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Age-specific positivity rate of SARS-CoV-2 infection
Time Frame: 15 months
|
Positivity rate by age-group (0-9, 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, >=70 years) of SARS-CoV-2 infection among acute respiratory syndrome individuals during 15 months
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15 months
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Age-specific Incidence of SARS-CoV-2 infection
Time Frame: 15 months
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Incidence by age-group (0-9.
10-19, 20-29, 30-39, 40-49, 50-59, 60-69, >=70 years) of SARS-CoV-2 infection among acute respiratory syndrome individuals during 15 months
|
15 months
|
Community Age-specific seroprevalence
Time Frame: month 5
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Seroprevalence by age-group (0-19, 20-39, 40-59, >=60 years) of IgM and IgG against SARS-CoV-2 at baseline andd after 15 months
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month 5
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Community Age-specific seroprevalence
Time Frame: month 11
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Seroprevalence by age-group (0-19, 20-39, 40-59, >=60 years) of IgM and IgG against SARS-CoV-2 at baseline andd after 15 months
|
month 11
|
Community Age-specific seroprevalence
Time Frame: month 14
|
Seroprevalence by age-group (0-19, 20-39, 40-59, >=60 years) of IgM and IgG against SARS-CoV-2 at baseline andd after 15 months
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month 14
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COVID-19 associated mortality
Time Frame: 2 years
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Factors associated with acute COVID-19, sero-positivity and COVID-19 associated mortality
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2 years
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
PCR and antibody-negativization
Time Frame: up to 12 months
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Median time (weeks or months) to PCR and antibody-negativization in symptomatic PCR-confirmed acute COVID-19 individuals
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up to 12 months
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Relatedness of SARS-CoV-2 genome
Time Frame: 15 months
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Monophyletic groups of closely related SARS-CoV-2 genome
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15 months
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Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 80/CNBS/20
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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