Association Between Embryo Implantation Rate and Maternal Age

Association Between Embryo Implantation Rate and Maternal Age in Different Embryo Transplantation Cycles: a Retrospective Cohort Study

To explore the relationship between maternal age and embryo implantation rate in patients undergoing assisted reproductive technology.

Study Overview

• Status: Completed
• Conditions: Infertility, Female

Detailed Description

The investigators designed a retrospective clinical trial conducted from January 2015 to December 2020 at the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School. Infertility was defined as the failure of a clinical pregnancy after 12 months or more of regular unprotected intercourse with the same marriage partner. Patients experiencing infertility no younger than the age of 20 who attended the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School for the first time and had experienced no less than one embryo transplantation between January 2015 and December 2019 were recruited. Patients who had experienced or canceled embryo transplantation cycles for any reason were excluded from this study. The gap year from December 2019 to December 2020 allowed researchers to follow up on the outcomes of pregnancies before 2020. Frozen cycles were performed when high-quality embryos existed to avoid unnecessary ovarian stimulation and oocyte retrieval processes. Investigators were blinded to the outcome of embryo transplantation, and information on pregnancy was gathered through telephone follow-up one year after transplantation.

• Study Type: Observational
• Enrollment (Actual): 17394

Contacts and Locations

Study Locations

• China
  • Jiangsu
    • Nanjing, Jiangsu, China, 210008
      • Reproductive Medicine Center, The affiliated Drum Towel Hospital of Nanjing University Medical School

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 50 years (ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Non-Probability Sample

Study Population

Infertile females no less than 20 years old who were attending our clinical center for the first time were enlisted. In total, 17394 patients suffering from primary or secondary infertility were enrolled in this study.

Description

Inclusion Criteria:

1. infertile patients
2. attended the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School for the first time
3. had experienced no less than one embryo transplantation between January 2015 and December 2019

Exclusion Criteria:

canceled embryo transplantation cycles for any reason

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Infertile females; No less than 20 years old who were attending our clinical center for the first time were enlisted

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
embryo implantation rate	Fetal heartbeat can be visualized via ultrasound in order to definitely confirm the implantation of the embryo	60 days after embryo transplantation

Collaborators and Investigators

• Sponsor: Nanjing University

Study record dates

Study Major Dates

• Study Start (ACTUAL): January 1, 2015
• Primary Completion (ACTUAL): December 31, 2019
• Study Completion (ACTUAL): December 31, 2020

Study Registration Dates

• First Submitted: January 29, 2022
• First Submitted That Met QC Criteria: January 29, 2022
• First Posted (ACTUAL): February 9, 2022

Study Record Updates

• Last Update Posted (ACTUAL): February 22, 2022
• Last Update Submitted That Met QC Criteria: February 21, 2022
• Last Verified: February 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Infertility; Infertility, Female
• Other Study ID Numbers: SZ-2021-RIF

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No