Intensive Care Unit Activity in France From the National Database Between 2013 and 2019 (ICU_ACTIVITY)

Intensive Care Unit Activity in France From the National Database Between 2013 and 2019: More Critically Ill Patients, Shorter Stay and Lower Mortality Rate

Using data from the French National Uniform Hospital Discharge Database (systematically collecting administrative and medical information related to all hospitalized patients in France for care reimbursement purposes), the present study retrospectively assesses the activity of the French Intensive Care Unit (ICU)(1,594,801 ICU admissions):

• In-ICU and in-hospital mortality rates
• Length of stay in ICU and hospital
• Mortality-associated factors during the study period.
• Number of organ failures
• Bed occupancy,
• Regional variations in previous indicators

Study Overview

• Status: Completed
• Conditions: Critical Illness; Intensive Care Unit

• Study Type: Observational
• Enrollment (Actual): 1594801

Contacts and Locations

Study Locations

• France
  • Nîmes, France, 30029
    • Intensive care Unit CHU Nîmes

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All adults patients admitted in French ICU between January 1st, 2013, to December 31st, 2019

Description

Inclusion Criteria:

All adults patients admitted in French ICU between January 1st, 2013, to December 31st, 2019

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
ICU ADMISSION; All patients admitted in a French intensive care unit over a 7-year period (2013 to 2019) using the French National Uniform Hospital Discharge Database (PMSI)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evolution in mortality rate	evolution of the mortality rate of ICU patients over the study period (2013-19)	from January 1st, 2013, to December 31st, 2019
Evolution in organ failure rate	evolution of the organ failure rate of ICU patients over the study period (2013-19)	from January 1st, 2013, to December 31st, 2019
Evolution in ICU stay	evolution of the ICU stay of ICU patients over the study period (2013-19)	from January 1st, 2013, to December 31st, 2019
Evolution in SAPS (Simplified Acute Physiology Score) II score at admission	evolution of the SAPS II score at admission of ICU patients over the study period (2013-19)	from January 1st, 2013, to December 31st, 2019
Evolution in age at admission	evolution of the age at admission of ICU patients over the study period (2013-19)	from January 1st, 2013, to December 31st, 2019
Evolution in sex ratio	evolution of the sex ratio of ICU patients over the study period (2013-19)	from January 1st, 2013, to December 31st, 2019

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Proportion of patients admitted in ICU with at least 2 different organ failures	evolution of the proportion of patients admitted in ICU with at least 2 different organ failures corresponding to the definition of ICU in France.	from January 1st, 2013, to December 31st, 2019
- Proportion of patients admitted in ICU with a SAPS II score over 15 and with a specific ICU supportive therapy	Evolution of the proportion of patients admitted in ICU with a SAPS II score over 15 and with a specific ICU supportive therapy leading to a reimbursement by the French national health insurance.	from January 1st, 2013, to December 31st, 2019
Factors Associated with in-ICU mortality	Effect of year-time on in-ICU mortality	from January 1st, 2013, to December 31st, 2019
Regional variations	Evolution and potential differences between French regions in admission level	from January 1st, 2013, to December 31st, 2019

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Nīmes
• Investigators: Principal Investigator: Jean Yves LEFRANT, Centre Hospitalier Universitaire de Nimes

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2013
• Primary Completion (Actual): December 31, 2019
• Study Completion (Actual): December 31, 2019

Study Registration Dates

• First Submitted: April 25, 2022
• First Submitted That Met QC Criteria: April 25, 2022
• First Posted (Actual): April 29, 2022

Study Record Updates

• Last Update Posted (Actual): April 29, 2022
• Last Update Submitted That Met QC Criteria: April 25, 2022
• Last Verified: April 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Critical Illness
• Other Study ID Numbers: LOCAL/2022/JYL-01

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No