The Prevalence of Chronic Critical Illness in Turkey

The Prevalence of Chronic Critical Illness Adult Intensive Care Units in Turkey

It is known that the number of Chronic Critical İllnes, an iatrogenic condition, increases all over the world. The prevalence of Chronic Critical Illness in Turkey is unknown. The investigators aimed to evaluate the etiology, comorbid conditions, demographic data, prevalence, mortality and costs of these patient in intensive care units in Turkey. In this multi-centered study, The investigators will retrospectively review the last 1 year of patients receiving treatment at the Adult Intensive Care Unit.

Study Overview

• Status: Completed
• Conditions: Chronic Critical Illness

Detailed Description

The patients who survive an acute critical illness in the Intensive Care Unit (ICU) may be delayed in a situation where they are sometimes totally independent before hand due to iatrogenic causes such as infections, dysfunctions, psychological disorders. This can take weeks, sometimes months. This disease is called "Chronic Critical Illness" (CCI).

Most researchers associate CCI with the need for prolonged acute mechanical ventilation or the opening of tracheostomy for prolonged acute mechanical ventilation. There is no single condition that does not require an extended mechanical ventilation from CCI. In conclusion, CCI is characterized by long-term care requiring survival and it is predicted that the cost of these patients will increase with the new patients whose cost will be added in the coming years. In the United States, the number of CCI is around 250,000, and this figure has increased by 50-100% in the last 10 years. At least 50% of these patients die in one year and less than 12% recover and become discharged. The annual cost of these patients' health care system is over $ 20 billion. The prevalence of CCI in Turkey is still unknown. In this study, it was aimed to investigate the prevalence of patients with Chronic Critical Syndrome in intensive care units in Turkey.

• Study Type: Observational
• Enrollment (Actual): 2493

Contacts and Locations

Study Locations

• Turkey
  • Van, Turkey, 65080
    • Yuzuncu Yıl University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

The patient older than 18 years old staying in the intensive care unit longer than 8 days

Description

Inclusion Criteria:

The patient who is over 18 years old, taking mechanical ventilation support and staying in the critical care unit at least 8 days. Additional criterias; Clinical diagnosis of following situations:

1. Prolonged mechanical ventilation
2. Tracheotomia
3. Sepsis
4. Serious injury (burn)
5. Stroke ( hemorhagic or ischemic)
6. Traumatic brain injury

Exclusion Criteria:

1. The patients who not having mechanical ventilation support
2. The patient staying less than 8 days in the intensive care unit
3. The patient younger than 18 years old

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Chronic Critical Illness; The patients who is over 18 years old and staying in the critical care unit at least 8 days. Additional criterias: Prolonged mechanical ventilation (longer than 96 hours); Tracheostomy; Sepsis; Serious injury (burn); Stroke (hemorhagic or ischemic); Traumatic brain injury

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Critical care unit mortality	The mortality change rates in the 30th days and 90th days	30 day and 90 day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Critical care unit costs	Costs of patients staying in the intensive care unit	Duration of intensive care unit stay (8 day after the hospitalisation to sixth month)

Collaborators and Investigators

• Sponsor: Yuzuncu Yıl University
• Collaborators: Kahramanmaras Sutcu Imam University; Izmir Ataturk Training and Research Hospital
• Investigators: Principal Investigator: Hilmi Demirkıran, Official of the university

Study record dates

Study Major Dates

• Study Start (ACTUAL): September 1, 2017
• Primary Completion (ACTUAL): December 1, 2018
• Study Completion (ACTUAL): April 28, 2019

Study Registration Dates

• First Submitted: August 18, 2017
• First Submitted That Met QC Criteria: August 24, 2017
• First Posted (ACTUAL): August 25, 2017

Study Record Updates

• Last Update Posted (ACTUAL): October 10, 2019
• Last Update Submitted That Met QC Criteria: October 8, 2019
• Last Verified: October 1, 2019

More Information

Terms related to this study

• Keywords: Tracheotomy; Prolonged akut mechanical ventilation
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Critical Illness
• Other Study ID Numbers: Chronic critical illness

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No